Evidence map›Paper›PMID 42078120›Full record

ArticleMedicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents2026

Dynamic tail amine interactions drive isoform selectivity for potent human neuronal nitric oxide synthase inhibitors.

Amardeep Awasthi, Koon Mook Kang, Richard B Silverman

Abstract read
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In one paragraph

Article in Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Amardeep AwasthiDepartment of Chemistry, Chemistry of Life Processes Institute, Center for Developmental Therapeutics, Northwestern University, 2145 Sheridan Road, Evanston, Illinois 60208-3113 US.
Koon Mook KangDepartment of Chemistry, Chemistry of Life Processes Institute, Center for Developmental Therapeutics, Northwestern University, 2145 Sheridan Road, Evanston, Illinois 60208-3113 US.
Richard B SilvermanDepartment of Chemistry, Chemistry of Life Processes Institute, Center for Developmental Therapeutics, Northwestern University, 2145 Sheridan Road, Evanston, Illinois 60208-3113 US.

Funding

Selective inhibition of nitric oxide synthase for multiple indicationsR35GM131788 · NIGMS · NORTHWESTERN UNIVERSITY · PI SILVERMAN, RICHARD B · 2019 to 2023
$2.3M
Development of small molecule selective inhibitors of neuronal nitric oxide synthase (nNOS) for melanoma treatmentR01CA303584 · NCI · CHAPMAN UNIVERSITY · PI SUN YANG · 2025 to 2026
$1.2M
NCI NIH HHS R01 CA303584NIGMS NIH HHS R35 GM131788
6 · The paper itself

Abstract

Achieving isoform-selective inhibition of neuronal nitric oxide synthase (nNOS) remains a significant challenge due to the high structural similarity with other NOS isoforms. Here, we report the design, synthesis, and characterization of novel nNOS inhibitors

Indexed as

cation–π interactionCNS permeabilityisoform selectivitymolecular dynamicsneuronal nitric oxide synthasestructure-based drug design

Identifiers

PMID42078120
PMCPMC13128701

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.