Evidence map›Paper›PMID 42078119›Full record

ArticleMedicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents2026

Inactivation of ornithine aminotransferase by (1

Koon Mook Kang, Abigail L Vargas, Wei Zhu, Inna Sokolenko, Dali Liu, Richard B Silverman

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Koon Mook KangDepartment of Chemistry, Northwestern University, Evanston, IL USA.
Abigail L VargasDepartment of Chemistry and Biochemistry, Loyola University Chicago, Chicago, IL USA.
Wei ZhuDepartment of Chemistry, Northwestern University, Evanston, IL USA.
Inna SokolenkoDepartment of Chemistry, Northwestern University, Evanston, IL USA.
Dali LiuDepartment of Chemistry and Biochemistry, Loyola University Chicago, Chicago, IL USA.
Richard B SilvermanDepartment of Chemistry, Northwestern University, Evanston, IL USA.

Funding

New Inactivators of GABA Aminotransferase for Addiction and EpilepsyR01DA030604 · NIDA · NORTHWESTERN UNIVERSITY · PI SILVERMAN, RICHARD B · 2011 to 2020
$4.0M
Ornithine Aminotransferase Inactivation, a New Approach for Treatment of CancersR01CA260250 · NCI · NORTHWESTERN UNIVERSITY · PI RICHARD B SILVERMAN · 2021 to 2026
$2.3M
STRUCTURAL BIOL RES: LUNG SURFACTANT PROTEINS, DISTRESSS10RR019071 · NCRR · NORTHWESTERN UNIVERSITY · PI RADHAKRISHNAN, ISHWAR · 2005 to 2005
$272k
600 MHz NMR Instrument Upgrade at Northwestern UniversityS10OD012016 · OD · NORTHWESTERN UNIVERSITY · PI RADHAKRISHNAN, ISHWAR · 2012 to 2012
$267k
NCI NIH HHS R01 CA260250NCRR NIH HHS S10 RR019071NIDA NIH HHS R01 DA030604NIH HHS S10 OD012016
6 · The paper itself

Abstract

Ornithine aminotransferase (OAT), a pyridoxal 5'-phosphate (PLP)-dependent enzyme, is a key contributor to glutamine supply in cancer cells, suggesting its therapeutic potential for hepatocellular carcinoma (HCC), the most common form of liver cancer. To identify an initial set of OAT inactivators, we have tested inactivators of γ-aminobutyric acid aminotransferase (GABA-AT), a homologous PLP-dependent enzyme, with human OAT (

Indexed as

Hepatocellular carcinomaMechanism-based inactivatorOrnithine aminotransferasePyridoxal 5’-phosphate-dependent enzymeStable quinonoid intermediateX-ray crystallography

Identifiers

PMID42078119
PMCPMC13128779

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.