Evidence map›Paper›PMID 42078114›Full record

ArticleNPJ dementia2026

Cognitive impairment and its associated health conditions in American Indian communities.

Wenjun Fan, Jiahui Dai, Yuxi Shi, Erin M Poole, Joan O'Connell, Spero M Manson, Luohua Jiang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NPJ dementia, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Incidence and risk factors for AD/ADRD among American Indian and Alaska Native US Veterans.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Wenjun Fan *Department of Epidemiology & Biostatistics, Joe C. Wen School of Population & Public Health, Susan and Henry Samueli College of Health Sciences, University of California, Irvine, CA USA.
Jiahui Dai *Department of Epidemiology & Biostatistics, Joe C. Wen School of Population & Public Health, Susan and Henry Samueli College of Health Sciences, University of California, Irvine, CA USA.
Yuxi ShiDepartment of Epidemiology & Biostatistics, Joe C. Wen School of Population & Public Health, Susan and Henry Samueli College of Health Sciences, University of California, Irvine, CA USA.
Erin M PooleCenters for American Indian and Alaska Native Health, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora, CO USA.
Joan O'ConnellCenters for American Indian and Alaska Native Health, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora, CO USA.
Spero M MansonCenters for American Indian and Alaska Native Health, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora, CO USA.
Luohua JiangDepartment of Epidemiology & Biostatistics, Joe C. Wen School of Population & Public Health, Susan and Henry Samueli College of Health Sciences, University of California, Irvine, CA USA.

Funding

Research Education CoreP30AG015292 · NIA · UNIVERSITY OF COLORADO DENVER · PI MANSON, SPERO MARTIN · 1997 to 2022
$12.3M
Longitudinal Study of MRI, Clinical, and Genetic Biomarkers of Cognitive Impairment and Alzheimer's Disease in Elderly American IndiansU54MD000507 · NIMHD · UNIVERSITY OF COLORADO DENVER · PI BUCHWALD, DEDRA S · 2017 to 2021
$6.5M
NIA NIH HHS P30 AG015292NIMHD NIH HHS U54 MD000507
6 · The paper itself

Abstract

This cross-sectional study examined cognitive impairment and its associations with health conditions among American Indian (AI) adults aged ≥55 residing in the Pacific Northwest, Rocky Mountains, and Northern Plains from 2019 to 2023. Subjective cognitive impairment was assessed using the adapted AD8, a culturally tailored eight-item measure to differentiate aging and dementia. Among 712 AI adults surveyed, 34.3% had cognitive impairment, with the highest proportion observed among those aged 55-59 (40.3%). Results from negative binomial regression indicated that distress [prevalence rate ratio (PRR) = 2.25, 95% confidence interval (CI): (1.31-3.87)], head injury [PRR = 1.58, 95% CI: (1.00-2.51)], and diabetes [PRR = 1.59, 95% CI: (1.21-2.10)] were significantly associated with worse cognitive performance. Additionally, the findings suggest a high prevalence of cognitive impairment in this AI sample of convenience. Furthermore, associations between several health conditions and cognitive function differ by age groups. Early screening for cognitive impairment using tools like AD8 is recommended for AI adults.

Indexed as

Cognitive ageingPublic health

Identifiers

PMID42078114
PMCPMC13128437

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.