Evidence map›Paper›PMID 42078011›Full record

ArticleRedox biochemistry and chemistry2025

Chemical Mechanisms of Lipid Peroxidation.

Ned A Porter

Abstract read
In one paragraph

Article in Redox biochemistry and chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. PROTACs in cancer therapy: targeted degradation of GPX4, PARP and epigenetic regulators.Journal of enzyme inhibition and medicinal chemistry · 2026
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Ned A PorterDepartment of Chemistry and Institute of Chemical Biology, Vanderbilt University, Nashville, TN; 37235.

Funding

Protein Adducts and Proteome Profiles in Oxidative StressP01ES013125 · NIEHS · VANDERBILT UNIVERSITY · PI PORTER, NED ALLEN · 2005 to 2012
$12.6M
Ozone, oxysterols, and lung inflammationR01ES028269 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI JASPERS, ILONA, PORTER, NED ALLEN · 2018 to 2023
$2.8M
FREE RADICALS, LIPIDS AND ENZYME PHOTOACTIVATIONR37HL017921 · NHLBI · VANDERBILT UNIVERSITY · PI PORTER, NED · 1996 to 2005
$2.8M
Vulnerability of DHCR7+/- mutation carriers to aripiprazole and trazodone treatmentR01MH110636 · NIMH · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI MIRNICS, KAROLY, PORTER, NED ALLEN · 2017 to 2021
$2.7M
Ozone, lipid-protein adducts, and biological effectsR21ES024666 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI JASPERS, ILONA, PORTER, NED ALLEN · 2015 to 2016
$437k
NHLBI NIH HHS R37 HL017921NIEHS NIH HHS P01 ES013125NIEHS NIH HHS R01 ES028269NIEHS NIH HHS R21 ES024666NIMH NIH HHS R01 MH110636
6 · The paper itself

Abstract

The chemical framework for free radical chain oxidation of naturally-occurring lipids, commonly referred to as peroxidation, has provided a basis for understanding important processes in biology. H-atom transfer to peroxyl free radicals and olefin addition of those radicals are the primary rate-determining steps in peroxidation, but the lipid carbon radicals generated in these primary steps have multiple mechanistic pathways available. Oxygen addition, homolytic intramolecular substitution (

Identifiers

PMID42078011
PMCPMC13134691

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.