ArticleFrontiers in public health2026
A multianalyte method for simultaneous evaluation of occupational exposure to anesthetic gases in urine samples from healthcare professionals.
Article in Frontiers in public health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Monitoring occupational exposure in hospital settings requires valid non-invasive exposure assessment methods. We aimed to develop a multianalyte method to characterize and quantify urinary levels of anesthetic gases in healthcare professionals. Methods: Urine samples were collected from 37 recently exposed and 24 non-exposed professionals. A multianalyte method was developed and validated to determine urinary concentrations of desflurane, isoflurane, sevoflurane, and its main metabolite, hexafluoroisopropanol, using headspace gas chromatography coupled to mass spectrometry (HS-GC-MS). Results: The methodology was successfully validated. It demonstrated adequate linearity and sensitivity [correlation coefficients ( Conclusion: A multianalyte HS-GC-MS method was successfully developed to simultaneously determine four anesthetic gases in urine samples and was validated in real-world samples from healthcare professionals. Future studies are needed to investigate the safety of exposure to these compounds for anesthesiologists and operating room nurses.
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