Evidence map›Paper›PMID 42077910›Full record

ArticleACS omega2026

Influence of Chondroitin Sulfate Concentration on the Physicochemical Properties of Acetaminophen-Releasing Cellulose/PVOH Membranes.

Juliano Brisola, Paula Paulino Silva, Francisnara Tonholi, Jéssica Bassetto Carra, Rúbia Casagrande, Paulo Rodrigo Stival Bittencourt, Gizilene Maria de Carvalho

Abstract read
In one paragraph

Article in ACS omega, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Juliano BrisolaDepartment of Chemistry, State University of Londrina, Londrina 86057-970, Brazil.ORCID https://orcid.org/0000-0003-0369-8013
Paula Paulino SilvaDepartment of Chemistry, State University of Londrina, Londrina 86057-970, Brazil.
Francisnara TonholiDepartment of Chemistry, State University of Londrina, Londrina 86057-970, Brazil.
Jéssica Bassetto CarraDepartment of Chemistry, State University of Londrina, Londrina 86057-970, Brazil.
Rúbia CasagrandeDepartment of Pharmaceutical Sciences, State University of Londrina, Londrina 86057-970, Brazil.
Paulo Rodrigo Stival BittencourtDepartment of Chemistry, Federal University of TechnologyParaná (UTFPR), Medianeira Campus, Medianeira 85722-332, Paraná, Brazil.ORCID https://orcid.org/0000-0001-8740-1672
Gizilene Maria de CarvalhoDepartment of Chemistry, State University of Londrina, Londrina 86057-970, Brazil.ORCID https://orcid.org/0000-0001-9514-7897

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The integrity of the skin barrier is essential for protecting the body from external threats. However, mechanical trauma, thermal injuries, and chronic wounds can impair this barrier and increase susceptibility to secondary infections. Wound dressings capable of in situ drug release and skin regeneration have emerged as effective strategies to promote accelerated healing. Cellulose/poly-(vinyl alcohol) (Cel/PVOH) and cellulose/chondroitin sulfate (Cel/CS) membranes are particularly promising for this purpose. However, it is essential to understand how increasing the chondroitin sulfate content affects the physical and chemical properties of these membranes. In this study, Cel/PVOH membranes incorporated with acetaminophen were developed, with varying amounts of chondroitin sulfate. Structural characterization by FT-IR and XRD revealed that higher CS content reduced crystallinity, thermal stability, and water vapor permeability. SEM analysis showed increased surface porosity associated with CS incorporation. Membranes with higher CS levels exhibited enhanced fluid handling capacity (FHC), ranging from 3.48 to 5.15 g·10 cm

Identifiers

PMID42077910
PMCPMC13130104

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.