ArticleACS omega2026
New Synthetic Approach to C‑30 Ethers, Esters, and Amines of Betulin Using the Mitsunobu Reaction and Biological Evaluation of the Products.
Article in ACS omega, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
8 authors.
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Abstract
A novel three-step synthetic approach for modification of betulin at position C-30 was developed starting from commercially available betulin diacetate. The scope of this procedure exceeds significantly the previously used methods while providing higher yields. The final Mitsunobu reaction was the pivotal step of the synthesis, and after optimization, 39 new derivativesethers, esters, and amineswere synthesized in good to high yields. All the novel compounds were tested for
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