Evidence map›Paper›PMID 42077889›Full record

ArticleACS omega2026

Therapeutic Potential of Vanillylacetone in Ameliorating CCl4-Induced Cardiotoxicity by targeting TNF-α/ NF-κB/TGF-β1 Pathways: Evidence from Biochemical, Histopathological, and Computational Analyses.

Mohammad Firoz Alam, Nouf A S Altowairqi, Wedad Mawkili, Ambreen Shoaib, Jamal-E Fatima, Majed A Dallak, Dhaifallah A I Abu Rabtah, Ali Mohammed Ali Hazazi, Abdulmajeed M Jali, Tarique Anwer and 3 more

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Article in ACS omega, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Mohammad Firoz AlamDepartment of Pharmacology and Toxicology, College of Pharmacy, Jazan University, Jazan 45142, KSA.ORCID https://orcid.org/0000-0002-4716-8658
Nouf A S AltowairqiDepartment of Pharmacology and Toxicology, College of Pharmacy, Jazan University, Jazan 45142, KSA.
Wedad MawkiliDepartment of Pharmacology and Toxicology, College of Pharmacy, Jazan University, Jazan 45142, KSA.
Ambreen ShoaibDepartment of Pharmacy Practice, Jazan University, Jazan 45142, Saudi Arabia.ORCID https://orcid.org/0000-0002-6562-8945
Jamal-E FatimaSchool of Electronic Science and Engineering, University of Electronic Science and Technology of China, Chengdu 610054, China.
Majed A DallakDepartment of Pharmacology and Toxicology, College of Pharmacy, Jazan University, Jazan 45142, KSA.
Dhaifallah A I Abu RabtahDepartment of Pharmacology and Toxicology, College of Pharmacy, Jazan University, Jazan 45142, KSA.
Ali Mohammed Ali HazaziDepartment of Pharmacology and Toxicology, College of Pharmacy, Jazan University, Jazan 45142, KSA.
Abdulmajeed M JaliDepartment of Pharmacology and Toxicology, College of Pharmacy, Jazan University, Jazan 45142, KSA.
Tarique AnwerDepartment of Public Health, College of Applied Medical Sciences, University of Bisha, P.O Box 225, Bisha 67714, Saudi Arabia.
Marwa QadriDepartment of Pharmacology and Toxicology, College of Pharmacy, Jazan University, Jazan 45142, KSA.
Maisa Yahya Al-MasrahiDepartment of Pharmacology and Toxicology, College of Pharmacy, Jazan University, Jazan 45142, KSA.
Abdulaziz AlarifiDepartment of Basic Sciences, College of Science and Health Professions, King Saud bin Abdulaziz University for Health Sciences, Riyadh 11481, Saudi Arabia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The hepatotoxicity of carbon tetrachloride is widely established, although due to the paucity of research, it is not as well-known as cardiotoxicity. This research investigates the cardiotoxic effects of carbon tetrachloride in Swiss albino mice through both in vivo and in silico methodologies. Vanillylacetone is a bioactive compound found in ginger, renowned for its potent therapeutic properties, including antioxidant and anti-inflammatory effects. The present research was conducted on mice, and they were categorized into five groups (G1-G5). G1 served as a control, G2 experienced CCl

Identifiers

PMID42077889
PMCPMC13129854

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.