ArticleACS omega2026
Phenanthrene Exposure Induces Immune Dysfunction and Metabolic Disruption in Mice.
Article in ACS omega, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Polycyclic aromatic hydrocarbons (PAHs) are widespread environmental pollutants that may impair immune function. However, the immunotoxic mechanisms of PAH exposure remain largely unexplored. The present study was designed as a mechanistic, effect-oriented investigation, in which male C57BL/6J mice were exposed to phenanthrene via intraperitoneal injection for six consecutive weeks. We assessed toxicological effects of phenanthrene exposure in mice through urinary metabolite profiling, hematological and immunological tests, and serum metabolomics. Urinary concentrations of phenanthrene metabolites demonstrated a clear dose-dependent increase across exposure groups, confirming internal accumulation. Relative organ weight analysis revealed significantly elevated kidney and lung weights in all exposed groups compared with controls. Hematological analysis revealed alterations in leukocyte subpopulations. Flow cytometric analysis showed that lymphocyte percentages among splenic cells were significantly decreased in phenanthrene-exposed mice compared with controls, with reductions of 13.74%, 24.92%, and 27.41% in the low-, medium-, and high-dose groups, respectively. The proportions of CD3
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