Evidence map›Paper›PMID 42077878›Full record

ArticleACS omega2026

Optimization of Antifungal 1,5-Diaryl-Pyrazole Acetyl-CoA Synthetase Inhibitors.

Jonah P Propp, Jeffrey C Ferreira, Parisa Enayati, Kathryn M Alden, Drashti G Daraji, Charles L Lail, Michael E Heene, Andrew J Jezewski, Rohan Wakade, Damien Castor and 3 more

Abstract read
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In one paragraph

Article in ACS omega, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Jonah P ProppDepartment of Pediatrics, Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, United States.
Jeffrey C FerreiraDepartment of Chemistry and Biochemistry, Northern Illinois University, DeKalb, Illinois 60115, United States.
Parisa EnayatiDepartment of Chemistry and Biochemistry, Northern Illinois University, DeKalb, Illinois 60115, United States.
Kathryn M AldenDepartment of Pediatrics, Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, United States.ORCID https://orcid.org/0000-0001-5339-1509
Drashti G DarajiDepartment of Chemistry and Biochemistry, Northern Illinois University, DeKalb, Illinois 60115, United States.
Charles L LailDepartment of Chemistry and Biochemistry, Northern Illinois University, DeKalb, Illinois 60115, United States.
Michael E HeeneDepartment of Chemistry and Biochemistry, Northern Illinois University, DeKalb, Illinois 60115, United States.
Andrew J JezewskiDepartment of Pediatrics, Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, United States.ORCID https://orcid.org/0000-0002-2004-1278
Rohan WakadeDepartment of Pediatrics, Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, United States.
Damien CastorDepartment of Pediatrics, Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, United States.
Noelle S WilliamsDepartment of Biochemistry, UT Southwestern Medical Center, Dallas, Texas 75390, United States.
Timothy J HagenDepartment of Chemistry and Biochemistry, Northern Illinois University, DeKalb, Illinois 60115, United States.
Damian J KrysanDepartment of Pediatrics, Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, United States.ORCID https://orcid.org/0000-0001-6330-3365

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Acetyl-CoA Synthetases (ACS) have emerged as a potential drug target for the treatment of diseases ranging from fungal and parasitic infections to cancer and hyperlipidemia. While species-selective ACS inhibitors have been reported, broad-spectrum inhibition of ACS enzymes has only been achieved with nucleoside-derived, bisubstrate analogs such as alkyl esters of adenosine monophosphate (AMP). Previously, we identified the diaryl pyrazole AR-12 as a non-nucleoside inhibitor of

Identifiers

PMID42077878
PMCPMC13130119

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.