Copper(I)-Catalyzed Stereoselective Synthesis of 4‑(Aminomethylene)-1,4-dihydroisoquinolin-3-ones from 4‑Diazo-1,4-dihydroisoquinolin-3-ones and Thioamides.

Yingxiao Wang, Jiale Fan, Tian-Yi Chen, Xin Hong, Ping Lu, Yanguang Wang

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Article in ACS omega, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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6 authors.

Yingxiao WangDepartment of Chemistry, Zhejiang University, Hangzhou 310058, P. R. China.

Jiale FanDepartment of Chemistry, Zhejiang University, Hangzhou 310058, P. R. China.

Tian-Yi ChenDepartment of Chemistry, Zhejiang University, Hangzhou 310058, P. R. China.

Xin HongDepartment of Chemistry, Zhejiang University, Hangzhou 310058, P. R. China.ORCID https://orcid.org/0000-0003-4717-2814

Ping LuDepartment of Chemistry, Zhejiang University, Hangzhou 310058, P. R. China.ORCID https://orcid.org/0000-0002-3221-3647

Yanguang WangDepartment of Chemistry, Zhejiang University, Hangzhou 310058, P. R. China.ORCID https://orcid.org/0000-0002-5096-7450

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6 · The paper itself

Abstract

A novel and efficient approach to synthesize 4-(aminomethylene)-1,4-dihydroisoquinolin-3-ones has been developed via a copper-(I)-catalyzed coupling reaction between 4-diazo-1,4-dihydroisoquinolin-3-ones and thioamides. This method yields products in good to excellent quantities with remarkable stereoselectivity. Notably, primary and secondary thioamides consistently produce the desired compounds with the (

Identifiers

PMID42077876

DOI10.1021/acsomega.6c01111

PMCPMC13130128

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