Evidence map›Paper›PMID 42077866›Full record

ArticleACS omega2026

Zwitterionic [Gd-(DOTA)] MRI Probes: Influence of Sulfobetaine Linker Length on Relaxivity.

Lennart F V Spickschen, David S Pusztai, Michael G Kaul, Verena R Schulze, Marie Oest, Aleksander J Swierzewski, Neus Feliu, Markus Fischer, Theophraste Lescot, Marc-André Fortin and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS omega, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Lennart F V SpickschenDepartment of Chemistry, Institute of Pharmacy, University of Hamburg, Bundesstrasse 45, Hamburg 20146, Germany.
David S PusztaiDepartment of Chemistry, Institute of Pharmacy, University of Hamburg, Bundesstrasse 45, Hamburg 20146, Germany.
Michael G KaulDepartment of Diagnostic and Interventional Radiology and Nuclear Medicine, Center of Radiology and Endoscopy, University Medical Center Hamburg-Eppendorf, Hamburg 20246, Germany.
Verena R SchulzeFraunhofer Institute for Applied Polymer Research IAP, Center for Applied Nanotechnology CAN, Grindelallee 117, Hamburg 20146, Germany.
Marie OestHamburg School of Food Science, Institute of Food Chemistry, University of Hamburg, Grindelallee 117, Hamburg 20146, Germany.
Aleksander J SwierzewskiDepartment of Chemistry, Institute of Pharmacy, University of Hamburg, Bundesstrasse 45, Hamburg 20146, Germany.
Neus FeliuFraunhofer Institute for Applied Polymer Research IAP, Center for Applied Nanotechnology CAN, Grindelallee 117, Hamburg 20146, Germany.
Markus FischerHamburg School of Food Science, Institute of Food Chemistry, University of Hamburg, Grindelallee 117, Hamburg 20146, Germany.
Theophraste LescotAxe Oncologie, Centre de Recherche du CHU de Québec-Université Laval, 2705, boul. Laurier, Québec, QC G1V 4G2, Canada.
Marc-André FortinAxe Oncologie, Centre de Recherche du CHU de Québec-Université Laval, 2705, boul. Laurier, Québec, QC G1V 4G2, Canada.ORCID https://orcid.org/0000-0002-8601-466X
John V FrangioniCuradel Pharma, 28120 Hunters Ridge Blvd, Suites 6-7, Bonita Springs, FL, Massachusetts 34135, United States.
Wolfgang MaisonDepartment of Chemistry, Institute of Pharmacy, University of Hamburg, Bundesstrasse 45, Hamburg 20146, Germany.ORCID https://orcid.org/0000-0003-2793-5722

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Macrocyclic chelators are a development platform for new Gd-(III)-based contrast agents (GBCAs) for magnetic resonance imaging. Zwitterionic modification of these Gd-(III)-complexes has been reported to improve their solubility, relaxivity, and stability, resulting in enhanced imaging performance and safety due to lower doses and reduced

Identifiers

PMID42077866
PMCPMC13129822

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.