ArticleACS omega2026
Ultrathin Electrospun Poly(γ-benzyl‑l‑glutamate) Nanofibrous Membranes for Retinal Pigment Epithelial Cell Cultivation.
Article in ACS omega, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
8 authors.
Funding
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Abstract
This study presents the preparation of ultrathin poly-(γ-benzyl-l-glutamate) nanofibrous membranes (PBLG-NfMs), approximately 5.1 μm thick, engineered as scaffolds for retinal pigment epithelial (RPE) cell cultivation. PBLG-NfMs exhibited high porosity and large pores. To enhance bioactivity, the membranes were modified using air plasma treatment to improve wettability, followed by modification with fibronectin, a key extracellular matrix protein that promotes cell adhesion and migration. Fibronectin adsorption and its uniform distribution across the nanofiber network were proven by X-ray photoelectron spectroscopy, scanning electron microscopy, and photoluminescence measurements. In vitro studies have demonstrated that such synthetic poly-(α-amino acid)-based membranes effectively support RPE cell viability, adhesion, and proliferation. Furthermore, immunocytochemical staining confirmed the expression of RPE-specific markers ZO-1 and RPE65, indicating preserved epithelial phenotype and functionality. These results highlight the potential of fibronectin-coated PBLG-NfMs as promising scaffolds for eye tissue engineering.
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Registered trials
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