Evidence map›Paper›PMID 42077848›Full record

ArticleACS omega2026

Wheat Peptides Promote Recovery of the Enteric Nervous System via mAChR Activation to Relieve Constipation in Mice.

Fei Shen, Guanghua He, Juan Du, Haiying Cai, Minjie Zhao, Jing Wang, Haobin Zhao, Lida Wang, Fengqin Feng, Qianqian Wang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS omega, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Fei ShenSchool of Biological and Chemical Engineering, Zhejiang University of Science & Technology, Hangzhou 310023, China.
Guanghua HeSchool of Biological and Chemical Engineering, Zhejiang University of Science & Technology, Hangzhou 310023, China.
Juan DuHangzhou Kangyuan Food Science & Technology Co., Ltd., Hangzhou 310012, China.
Haiying CaiSchool of Biological and Chemical Engineering, Zhejiang University of Science & Technology, Hangzhou 310023, China.ORCID https://orcid.org/0000-0002-8902-9269
Minjie ZhaoCollege of Biosystems Engineering and Food Science, National-Local Joint Engineering Laboratory of Intelligent Food Technology and Equipment, Zhejiang Key Laboratory for Agro-Food Processing, Zhejiang University, Hangzhou, 310058, China.
Jing WangCollege of Biosystems Engineering and Food Science, National-Local Joint Engineering Laboratory of Intelligent Food Technology and Equipment, Zhejiang Key Laboratory for Agro-Food Processing, Zhejiang University, Hangzhou, 310058, China.
Haobin ZhaoHangzhou Kangyuan Food Science & Technology Co., Ltd., Hangzhou 310012, China.
Lida WangDoppler Ultrasonic Department, Zhejiang Dermatology Hospital, Huzhou 311203, China.
Fengqin FengCollege of Biosystems Engineering and Food Science, National-Local Joint Engineering Laboratory of Intelligent Food Technology and Equipment, Zhejiang Key Laboratory for Agro-Food Processing, Zhejiang University, Hangzhou, 310058, China.ORCID https://orcid.org/0000-0002-9770-1721
Qianqian WangCollege of Food and Health, Zhejiang A & F University, Hangzhou 311300, China.ORCID https://orcid.org/0000-0001-6283-2257

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Constipation represents a prevalent gastrointestinal disorder. This study demonstrates that wheat peptides (WP) effectively ameliorate loperamide-induced constipation in mice. Administration of WP orally at 0.5 mg/g body weight led to significant improvements in defecation, small intestinal motility, and the integrity of the intestinal barrier. WP further modulated inflammatory markers and enteric nervous system (ENS) regulators while correcting gut microbiota dysbiosis through restoration of microbial diversity and taxonomic composition. Crucially, colon transcriptomics revealed WP-mediated activation of calcium signaling pathway genes and the acetylcholine receptor gene. RT-qPCR validation confirmed the upregulation of key effectors, including muscarinic acetylcholine receptor

Identifiers

PMID42077848
PMCPMC13129869

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.