ReviewCureus2026
The Crucial Function of Biomarkers in the Diagnosis and Management of Systemic Sclerosis-Associated Interstitial Lung Disease.
Review in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
There is a critical need for biomarkers for systemic sclerosis-associated interstitial lung disease (SSc-ILD) due to the high mortality rate associated with interstitial lung disease in patients with systemic sclerosis. The pathology of this condition remains poorly understood, highlighting the urgency for advancements in early diagnosis and detection. Biomarkers have the potential to provide a solution to this pressing issue; however, these biomarkers must be of high quality and reliability to aid in the management of SSc-ILD. Treatments are currently initiated following the onset of frank clinical manifestations. These clinical presentations naturally occur only after significant disease progression and tissue damage. Biomarkers may allow for earlier interventions, which may prevent reduced lung function. Biomarkers facilitate diagnostic reasoning processes and prognostic predictions in personalized patient management plans. In current clinical practice, using biomarkers in SSc-ILD is far from well-established. The background and explanation of why there is a near absence of validated biomarkers in this setting are reviewed in this article. The review aims to focus on the candidate markers that are to become routinely offered by pathology services, highlighting the biochemical and pathological rationale for their use.
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