ArticleCureus2026
Clinicopathological Characteristics and Survival Outcomes in Patients With Gastric Adenocarcinoma: A 16-Year Experience From a Single Tertiary Center in Tunisia.
Article in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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9 authors.
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Abstract
introductionGastric cancer remains a leading cause of cancer-related mortality worldwide, with marked geographic disparities in presentation and outcomes. Surgical resection remains the cornerstone of curative treatment; however, survival and recurrence patterns vary according to clinicopathological features.
objectiveThis study aimed to evaluate overall survival and recurrence outcomes after gastrectomy for patients with gastric adenocarcinoma and to identify independent prognostic factors in a North African tertiary-care setting. MATERIAL AND
methodsWe conducted a retrospective cohort study spanning 16 years, including 192 patients who underwent curative-intent or palliative gastrectomy for histologically confirmed gastric adenocarcinoma at a single tertiary center in Tunisia. Overall survival, locoregional recurrence, and distant metastasis were analyzed via the Kaplan-Meier method and Cox proportional hazards regression.
resultsThe overall survival rates were 57.5% at one year, 22% at five years, and 14% at 10 years. On multivariate analysis, residual tumor, larger tumor size, and advanced pathological stage were independently associated with poorer survival. Locoregional recurrence occurred in 21.7% of patients and was independently associated with subtotal gastrectomy (hazard ratio (HR) = 2.81). Distant recurrence was observed in 41.4% of the patients and was independently associated with serosal invasion (HR = 2.88; p = 0.023) and an infiltrative tumor growth pattern (HR = 3.49; p = 0.002).
conclusionThese findings underscore the need for optimized surgical strategies and tailored multimodal treatment approaches, particularly in regions where advanced-stage presentation remains common.
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