Evidence map›Paper›PMID 42077653›Full record

ArticleCurrent research in microbial sciences2026

Targeting the US21 viroporin of human cytomegalovirus by calcium channel blockers as a new antiviral strategy.

Giulia Sibille, Davide Loggia, Gianluca Catucci, Alessandra Gilardino, Alessandra Fiorio Pla, Giovanna Di Nardo, Luca Munaron, Gianfranco Gilardi, Giorgio Gribaudo, Anna Luganini

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Current research in microbial sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Giulia SibilleDepartment of Life Sciences and Systems Biology, University of Turin, 10123 Turin, Italy.
Davide LoggiaDepartment of Life Sciences and Systems Biology, University of Turin, 10123 Turin, Italy.
Gianluca CatucciDepartment of Life Sciences and Systems Biology, University of Turin, 10123 Turin, Italy.
Alessandra GilardinoDepartment of Life Sciences and Systems Biology, University of Turin, 10123 Turin, Italy.
Alessandra Fiorio PlaDepartment of Life Sciences and Systems Biology, University of Turin, 10123 Turin, Italy.
Giovanna Di NardoDepartment of Life Sciences and Systems Biology, University of Turin, 10123 Turin, Italy.
Luca MunaronDepartment of Life Sciences and Systems Biology, University of Turin, 10123 Turin, Italy.
Gianfranco GilardiDepartment of Life Sciences and Systems Biology, University of Turin, 10123 Turin, Italy.
Giorgio GribaudoDepartment of Life Sciences and Systems Biology, University of Turin, 10123 Turin, Italy.
Anna LuganiniDepartment of Life Sciences and Systems Biology, University of Turin, 10123 Turin, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The Human cytomegalovirus (HCMV) US21 protein is a calcium-conducting viroporin that modulates intracellular Ca

Indexed as

Antiviral activityapoptosisCalcium channel blockersCell migrationDrug repurposingHuman cytomegalovirusMolecular dynamics simulationsUS21 viroporin

Identifiers

PMID42077653
PMCPMC13129453

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.