Evidence map›Paper›PMID 42077646›Full record

ArticleEClinicalMedicine2026

Effect of an mHealth-assisted multifaceted lifestyle intervention on body-mass index, hepatic fat content and stiffness in children with overweight or obesity: a cluster randomised controlled trial.

Ping-Ping Zhang, Li Li, Hongqiao Fu, Enkar Nur, Duo Xu, Youxin Wang, Jiaying Gu, Miao Xu, Ye Zhou, Fangjing Shen and 9 more

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in EClinicalMedicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05482191 (Healthy Weight Management Project for Overweight and Obesity Children in Ningbo City), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05482191 naactive not recruitingnot on this map

Healthy Weight Management Project for Overweight and Obesity Children in Ningbo City

TypeinterventionalSponsorNingbo No. 1 HospitalRan2022 to 2025Enrolled331ConditionsObesityArmsLifestyle intervention
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Ping-Ping ZhangDepartment of Endocrinology and Metabolism, The First Affiliated Hospital of Ningbo University, Ningbo, China.
Li LiDepartment of Endocrinology and Metabolism, The First Affiliated Hospital of Ningbo University, Ningbo, China.
Hongqiao FuDepartment of Health Policy and Management, School of Public Health, Peking University, Beijing, China.
Enkar NurDepartment of Maternal and Child Health, School of Public Health, Peking University, National Health Commission Key Laboratory of Reproductive Health, Beijing, China.
Duo XuInstitute of Population and Labor Economics, Chinese Academy of Social Sciences, Beijing, China.
Youxin WangDepartment of Maternal and Child Health, School of Public Health, Peking University, National Health Commission Key Laboratory of Reproductive Health, Beijing, China.
Jiaying GuDepartment of Endocrinology and Metabolism, The First Affiliated Hospital of Ningbo University, Ningbo, China.
Miao XuDepartment of Endocrinology and Metabolism, The First Affiliated Hospital of Ningbo University, Ningbo, China.
Ye ZhouDepartment of Endocrinology and Metabolism, The First Affiliated Hospital of Ningbo University, Ningbo, China.
Fangjing ShenDepartment of Endocrinology and Metabolism, The First Affiliated Hospital of Ningbo University, Ningbo, China.
Xueying LiDepartment of Maternal and Child Health, School of Public Health, Peking University, National Health Commission Key Laboratory of Reproductive Health, Beijing, China.
Yunfei XingDepartment of Maternal and Child Health, School of Public Health, Peking University, National Health Commission Key Laboratory of Reproductive Health, Beijing, China.
Shifeng JinDepartment of Maternal and Child Health, School of Public Health, Peking University, National Health Commission Key Laboratory of Reproductive Health, Beijing, China.
Jialin LiDepartment of Endocrinology and Metabolism, The First Affiliated Hospital of Ningbo University, Ningbo, China.
Qifa SongMedical Data Center, The First Affiliated Hospital of Ningbo University, Ningbo, China.
Hui LiDivision of Health Promotion, Ningbo Municipal Center for Disease Control and Prevention, Ningbo, China.
Li Ming WenSydney School of Public Health, Faculty of Medicine and Health, The University of Sydney, Sydney, Australia.
Hui WangDepartment of Maternal and Child Health, School of Public Health, Peking University, National Health Commission Key Laboratory of Reproductive Health, Beijing, China.
Hai-Jun WangDepartment of Maternal and Child Health, School of Public Health, Peking University, National Health Commission Key Laboratory of Reproductive Health, Beijing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Lifestyle modification represents the cornerstone of the prevention and early management of obesity, hepatic fat content and stiffness in children. We aimed to evaluate the effectiveness of an mHealth-supported multifaceted lifestyle intervention on body-mass index (BMI), hepatic fat content and stiffness in children with overweight or obesity, and to estimate its potential long-term macroeconomic benefits. Methods: In this cluster randomised controlled trial, six primary schools in Ningbo, China, were randomly assigned (1:1) to an intervention or control group. Children aged 8-10 years with overweight or obesity were enrolled. The intervention integrated school-based health education and polices, physical activity promotion, dietary guidance delivered by clinical nutritionists, and supportive mHealth components. Primary outcomes were changes in BMI, controlled attenuation parameter (CAP), and liver stiffness measurement (LSM). Intention-to-treat analysis was performed using generalised linear mixed models accounting for school-level clustering and adjusting for baseline outcome values, age, and sex. A post-hoc macroeconomic simulation projected long-term economic effects. This trial is registered with ClinicalTrials.gov, NCT05482191. Findings: From 6 to 30 September, 2022, 331 children (mean age 8.5 years [SD 0.3]; 36.3% girls) were enrolled. Compared with controls, the intervention group showed significant reductions in BMI (mean difference -0.38 kg/m Interpretation: The mHealth-assisted lifestyle intervention significantly improved BMI, hepatic fat content and stiffness in children. The accompanying macroeconomic benefits support its integration into national public health and economic strategies. Funding: Major Science and Technology Projects for Health of Zhejiang Province; Cyrus Tang Foundation 2022.

Indexed as

Childhood obesityHepatic fat contentmHealthMultifaceted lifestyle intervention

Identifiers

PMID42077646
PMCPMC13133539

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.