ArticleACS applied optical materials2026
Polydopamine Nanoparticles as Label-Free Contrast Agents in Photoacoustic Imaging
Article in ACS applied optical materials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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12 authors.
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Abstract
Polydopamine nanoparticles (PDNPs) are a class of nanomaterials formed by the self-polymerization of dopamine. They exhibit high biocompatibility, biodegradability, antioxidant properties, and ease of functionalization and can serve as photothermal agents when exposed to near-infrared (NIR) light. Another notable feature of PDNPs is their potential to act as contrast agents in photoacoustic imaging (PAI). In this technique, light absorption by endogenous chromophores or nanostructures induces thermal expansion, which generates sound waves that can be exploited to create images. Although PDNPs have shown promise as PAI contrast agents, their capabilities remain underexplored and insufficiently characterized in biological systems. This study presents the first comprehensive evaluation of PDNPs as PAI contrast agents. We investigated PDNPs of various sizes (∼150-1000 nm) and assessed their photoacoustic performance in diverse environments, including aqueous dispersions,
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