ArticlePain reports2026
Whole-body vibration decreases pain and cartilage degeneration in male and female mice with osteoarthritis.
Article in Pain reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: Knee osteoarthritis (OA) is a chronic, degenerative joint disorder characterized by cartilage deterioration and persistent pain. Currently, there are no disease-modifying drugs and pharmacological treatments are unsatisfactory for OA. Objective: To investigate the therapeutic effects of whole-body vibration (WBV), a nondemanding physical intervention, on pain behaviors and cartilage morphology in male and female mice with knee OA. Methods: A medial meniscal transection (MMT) was used as a model that mimics meniscal tear-induced knee OA in patients. Animals were exposed to WBV (15-Hz frequency, 332-µm amplitude, 0.3 Results: Medial meniscal transection triggered mechanical hypersensitivity, reduced OA limb use, and induced cartilage damage in the medial and lateral compartments of femur and tibia, in both sexes. Whole-body vibration substantially alleviated mechanical hypersensitivity and improved limb use for up to 4 months after MMT, without affecting heat sensitivity, locomotor activity, or body weight. Furthermore, WBV considerably reduced the percentage of subchondral bone denuded of cartilage and increased cartilage thickness in the femur and tibia. Conclusion: These findings highlight the therapeutic potential of WBV as a nonpharmacological approach to relieve pain and restore cartilage integrity in knee OA.
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