Evidence map›Paper›PMID 42077513›Full record

ArticleFoot & ankle orthopaedics2026

Ankle Arthrodesis Associated With Risk of Progression to Total Knee Arthroplasty Compared to Total Ankle Arthroplasty.

Gloria Coden, Colin Wood, Andrzej Brzezinski, Matthew Beckles, Shannon Gray, Riley Smith, Kurt Hofmann

Abstract read
In one paragraph

Article in Foot & ankle orthopaedics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Gloria CodenDepartment of Orthopaedic Surgery, New England Baptist Hospital, Boston, MA, USA.
Colin WoodBoston Bone & Joint Institute, Waltham, MA, USA.ORCID https://orcid.org/0009-0000-8577-8919
Andrzej BrzezinskiDepartment of Orthopaedic Surgery, New England Baptist Hospital, Boston, MA, USA.
Matthew BecklesBoston Bone & Joint Institute, Waltham, MA, USA.ORCID https://orcid.org/0009-0009-8102-4912
Shannon GrayBoston Bone & Joint Institute, Waltham, MA, USA.ORCID https://orcid.org/0009-0007-0740-5413
Riley SmithBoston Bone & Joint Institute, Waltham, MA, USA.ORCID https://orcid.org/0009-0007-7524-7226
Kurt HofmannDepartment of Orthopaedic Surgery, New England Baptist Hospital, Boston, MA, USA.ORCID https://orcid.org/0000-0001-8852-8296

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: It is unknown how the increased range of motion and improved gait mechanics provided by total ankle arthroplasty (TAA) affects the progression of knee arthritis compared with ankle arthrodesis (AA). We hypothesized that patients treated with TAA would have a lower incidence of postoperative knee arthritis and total knee arthroplasty (TKA) compared with AA. Methods: We retrospectively reviewed a matched cohort of 3751 AAs and 3751 TAAs performed between January 1, 2007, and December 31, 2021, using a commercial claims database. Patients with a history of preoperative knee arthritis or TKA were excluded. Patients were matched 1:1 for gender, age at time of ankle surgery, indication for ankle surgery, year of ankle surgery, and geographical region. Univariate and multivariate regression analyses were performed. Significance was set at Results: Demographics were similar between AA and TAA. AA (absolute risk [AR] = 17.54%, odds ratio [OR] = 1.24, CI = 1.07-1.44), earlier years of ankle surgery, and older age increased the risk of postoperative knee arthritis compared with TAA (AR = 10.10%, absolute risk reduction [ARR] = 7.44%, CI = 5.89%-8.99%). Posttraumatic ankle arthritis, inpatient surgery, and surgery in the West region were protective against developing postoperative knee arthritis. AA (AR = 4.19%, OR = 2.37, CI = 1.65-3.39), earlier year of ankle surgery, males, and other indication for ankle surgery increased the risk of requiring a postoperative TKA compared with TAA (AR = 1.36%, ARR = 2.83%, CI = 2.09%-3.57%). Posttraumatic ankle arthritis and inpatient surgery were protective factors against requiring a TKA. Conclusion: There is a significantly higher incidence of patients who underwent TKA after AA compared with TAA, although the inability to confirm laterality in 38% of cases dilutes the hypothesis of a specific biomechanical association in the study. We recommend that surgeons carefully weigh the risks and benefits of TAA and AA with this in mind, especially in patients with minimal knee arthritis, as a potential strategy to mitigate risk of requiring TKA in the future. Level of Evidence: Level III, retrospective comparative study.

Indexed as

ankle arthrodesisankle arthroplastygait mechanicsknee arthritispost-traumatic arthritistotal knee arthroplasty

Identifiers

PMID42077513
PMCPMC13129307

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.