ArticleFrontiers in endocrinology2026
Pulse pressure mediation and hypertension modulation: the impact of TyG index on renal function deterioration in CKD patients under the CKM syndrome framework.
Article in Frontiers in endocrinology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Baseline versus cumulative cholesterol, high-density lipoprotein, and glucose index and stroke risk in individuals with cardiovascular-kidney-metabolic syndrome stages 0-3: evidence from the CHARLS study.Cardiovascular diabetology. Endocrinology reports · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Under the Cardiovascular-Kidney-Metabolic (CKM) syndrome framework, insulin resistance (IR) is the core driver of renal damage. The triglyceride-glucose (TyG) index is a validated IR surrogate, but existing evidence is mostly limited to cross-sectional data or single-source databases, failing to clarify the longitudinal progression of renal injury and underlying mechanisms. Methods: This study integrated two independent prospective cohorts: the national community-based CHARLS cohort (4,476 middle-aged and elderly participants, 2011-2015 follow-up) and a hospital-based KDIGO 2012-defined CKD cohort (396 patients, median 1,019-day follow-up). We analyzed the association of TyG index with eGFR decline (CHARLS) and ESRD (CJFH), with pulse pressure as mediator, hypertension as moderator, via regression, mediation, survival and nonlinear analyses. Results: Elevated baseline TyG index was independently associated with renal function deterioration in both cohorts. Pulse pressure played a partial mediating role in this association, while baseline hypertension significantly amplified the adverse renal effect of TyG. The overall association was dominated by a negative linear trend with no significant risk threshold. Conclusion: TyG index is an independent risk factor for renal function deterioration, with its adverse effects partially mediated by elevated pulse pressure and amplified by hypertension. This study provides epidemiological evidence for the CKM "metabolism-vascular-renal" axis, supporting TyG-based early renal risk stratification in the general population and multi-dimensional interventions for CKD patients.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.