ArticleFrontiers in endocrinology2026
The impact of COVID-19 infection on the live birth rate in fresh embryo transfer cycles.
Article in Frontiers in endocrinology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background and aims: It is important to clarify the impact of COVID-19 on ART outcomes and to develop evidence-based guidelines for deciding whether to proceed with or cancel Methods: This retrospective study analyzed 1,025 fresh embryo transfer cycles from January 2021 to January 2023. We compared pregnancy and neonatal outcomes between the non-infected group (n=762) and the COVID-19-infected group (n=263). Additionally, we stratified the infected group into subgroups by two criteria: time of infection, with or without fever and partner infection status, and further compared pregnancy outcomes of these subgroups. Univariate and multivariate logistic regression analyses were performed to assess differences in pregnancy and neonatal outcomes between non-infected and COVID-19-infected individuals. Results: The newborn's gender, birth height and birth weight were comparable between the infected and uninfected groups. However, the COVID-19 infection group exhibited a lower LBR with an adjusted odds ratio (OR) of 0.655 (95% confidence interval (CI: 0.483 to 0.887; Conclusion: COVID-19 infection was associated with a lower LBR in fET cycles, especially when: infection occurred 28-84 days before oocyte retrieval with fever ≥ 38.5°C, or dual-partner were infected. Subsequent multicenter studies enrolling a significantly larger cohort of infected women or couples are essential to validate this finding.
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