ReviewFrontiers in endocrinology2026
Endocrine-metabolic regulation during the transition period in dairy cows: mechanisms, biomarkers, and emerging diagnostics for subclinical ketosis.
Review in Frontiers in endocrinology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Analytical Technologies for Milk Component Analysis: A Review of Progress and Challenges.Foods (Basel, Switzerland) · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The transition period from late gestation to early lactation represents a phase of marked endocrine and metabolic adjustment in dairy cows, driven by rapidly increasing energy demands associated with the onset of milk production. Alterations in circulating insulin, growth hormone, insulin-like growth factor-1, and cortisol promote nutrient partitioning toward lactation, enhance adipose tissue lipolysis, and increase the release of non-esterified fatty acids (NEFAs) into the bloodstream. When hepatic oxidative capacity and triglyceride export mechanisms are exceeded, excess NEFA uptake favors ketogenesis and accumulation of ketone bodies, particularly β-hydroxybutyrate, resulting in subclinical ketosis (SCK). Although SCK lacks overt clinical signs, it is highly prevalent during early lactation and is associated with impaired immune function, increased susceptibility to postpartum disorders, reduced milk yield, and compromised reproductive performance. This review summarizes current knowledge on the endocrine regulation of lipid mobilization, hepatic metabolic flexibility, and immunometabolic adaptations that contribute to the development of SCK in transition dairy cows. Diagnostic approaches are discussed with emphasis on established biomarkers such as NEFA and β-hydroxybutyrate, milk-based infrared spectroscopy, and emerging biosensor-based technologies, highlighting their advantages, limitations, and applicability for herd-level monitoring. The review also integrates evidence on the economic consequences of SCK and recent advances in precision nutrition, molecular profiling, and machine-learning-based prediction tools that may support earlier detection and targeted management. This synthesis is intended to provide a consolidated overview of endocrine-metabolic mechanisms and diagnostic strategies relevant to subclinical ketosis in dairy cattle during the transition period.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.