Evidence map›Paper›PMID 42077409›Full record

ArticleInflammatory intestinal diseases

Leucine-Rich Alpha-2 Glycoprotein Is an Accurate Serum Marker for Endoscopic and Histological Remission in Ulcerative Colitis.

Ami Kawamoto, Toshimitsu Fujii, Shohei Tanaka, Sho Watanabe, Shohei Tomii, Kento Takenaka, Shuji Hibiya, Ryo Morikawa, Akiko Tamura, Hiromichi Shimizu and 4 more

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Article in Inflammatory intestinal diseases. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

14 authors.

Ami KawamotoEndoscopic Unit, Institute of Science Tokyo Hospital, Tokyo, Japan.
Toshimitsu FujiiDepartment of Gastroenterology and Hepatology, Institute of Science Tokyo, Tokyo, Japan.
Shohei TanakaDepartment of Gastroenterology and Hepatology, Musashino Red Cross Hospital, Tokyo, Japan.
Sho WatanabeDepartment of Gastroenterology, Soka Municipal Hospital, Soka, Japan.
Shohei TomiiDepartment of Human Pathology, Institute of Science Tokyo, Tokyo, Japan.
Kento TakenakaDepartment of Gastroenterology and Hepatology, Institute of Science Tokyo, Tokyo, Japan.
Shuji HibiyaEndoscopic Unit, Institute of Science Tokyo Hospital, Tokyo, Japan.
Ryo MorikawaDepartment of Gastroenterology and Hepatology, Institute of Science Tokyo, Tokyo, Japan.
Akiko TamuraDepartment of Gastroenterology and Hepatology, Institute of Science Tokyo, Tokyo, Japan.
Hiromichi ShimizuDepartment of Gastroenterology and Hepatology, Institute of Science Tokyo, Tokyo, Japan.
Masayuki KurosakiDepartment of Gastroenterology and Hepatology, Musashino Red Cross Hospital, Tokyo, Japan.
Tsunehito YauchiDepartment of Gastroenterology, Soka Municipal Hospital, Soka, Japan.
Kazuo OhtsukaEndoscopic Unit, Institute of Science Tokyo Hospital, Tokyo, Japan.
Ryuichi OkamotoDepartment of Gastroenterology and Hepatology, Institute of Science Tokyo, Tokyo, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Achieving both endoscopic and histological remission in ulcerative colitis (UC) is associated with improved clinical outcomes. There is a growing need for noninvasive methods to assess both remission states. This study investigates the utility of serum leucine-rich alpha-2 glycoprotein (LRG) as a biomarker for monitoring endoscopic and histological remission in patients with UC. Methods: Patients with UC who underwent colonoscopy from July 2020 to September 2021 at multiple centers in Japan were included to compare the accuracy of C-reactive protein (CRP) and LRG in detecting endoscopic and histological remission. Receiver operating characteristic curve analyses were performed and area under the curve (AUC) values were compared. Results: A total of 412 patients were identified. The median values of CRP and LRG were 0.07 mg/dL and 12.2 μg/mL, respectively. Endoscopic remission, as defined as Mayo endoscopic sub-score of 0 or 1, was observed in 188 patients, and histological remission, as defined as Geboes score <3.1, was observed in 156 patients. The AUC values for CRP and LRG for detecting endoscopic remission were 0.68 and 0.76, respectively, and the AUC values for CRP and LRG for detecting histological remission were 0.70 and 0.76, respectively. In both cases, the AUC for LRG was significantly higher than that of CRP ( Conclusion: LRG is superior to CRP in detecting both endoscopic and histological remission in patients with UC.

Indexed as

Histological remissionLeucine-rich alpha-2 glycoproteinUlcerative colitis

Identifiers

PMID42077409
PMCPMC13134848

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