Evidence map›Paper›PMID 42077402›Full record

ArticleJHLT open2026

Donor-recipient sex differences: Implications for immunologic outcomes but no impact on survival after lung transplantation.

Zsófia Rosselli, Thomas Gaisl, Carolin Steinack, Georg Lang, Ömer Senbaklavaci, Isabelle Opitz, Irina Lea Dubach, Silvia Ulrich, René Hage, Macé M Schuurmans

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JHLT open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Zsófia RosselliDivision of Pulmonology, University Hospital Zurich, 8091 Zurich, Switzerland.
Thomas GaislDivision of Pulmonology, University Hospital Zurich, 8091 Zurich, Switzerland.
Carolin SteinackDivision of Pulmonology, University Hospital Zurich, 8091 Zurich, Switzerland.
Georg LangFaculty of Medicine, University of Zurich, 8032 Zurich, Switzerland.
Ömer SenbaklavaciFaculty of Medicine, University of Zurich, 8032 Zurich, Switzerland.
Isabelle OpitzFaculty of Medicine, University of Zurich, 8032 Zurich, Switzerland.
Irina Lea DubachDivision of Pulmonology, University Hospital Zurich, 8091 Zurich, Switzerland.
Silvia UlrichDivision of Pulmonology, University Hospital Zurich, 8091 Zurich, Switzerland.
René HageDivision of Pulmonology, University Hospital Zurich, 8091 Zurich, Switzerland.
Macé M SchuurmansDivision of Pulmonology, University Hospital Zurich, 8091 Zurich, Switzerland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Sex-related immunological differences may influence outcomes after lung transplantation, but evidence remains inconsistent. Methods: We retrospectively analyzed 252 adults transplanted at the University Hospital Zurich (2015-2024). The primary endpoint was 5-year all-cause mortality; secondary endpoints included acute and chronic rejection, development of donor-specific antibodies (DSA), antibody-mediated rejection (AMR), and post-transplant infectious complications. Results: Mean age was 52.2 years. Underlying diagnoses differed by sex (pulmonary fibrosis more common in men, cystic fibrosis in women; Conclusion: While overall survival was unaffected, sex-specific alloimmune patterns suggest underlying biological differences that warrant further investigation.

Indexed as

AlloimmunityAntibody-mediated rejectionDonor-recipient mismatchDonor-specific antibodiesLung transplantationSex differences

Identifiers

PMID42077402
PMCPMC13133528

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.