ArticleFrontiers in behavioral neuroscience2026
Tannic acid attenuates glyphosate-based herbicide-induced dopaminergic neurotoxicity associated with motor dysfunction in mice.
Article in Frontiers in behavioral neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: Glyphosate, a widely used herbicide, has gained attention due to its potential link to neurobehavioral and dopaminergic dysfunctions. Data on interventions against glyphosate-induced neurotoxicity are limited. Hence, the neuroprotective role of tannic acid (TA), a polyphenolic anti-inflammatory and antioxidant agent, was investigated in mice chronically exposed to glyphosate-based herbicide (GBH). Methods: Male Swiss mice were randomly allocated into six groups ( Results: TA significantly inhibited GBH-induced motor dysfunction. As compared to the GBH group, TA treatments significantly (p < 0.0001) decreased midbrain malondialdehyde (MDA), TNF-α, IL-1β, and IL-6 levels. TA treatments increased significantly ( Discussion: These findings are suggestive of the neuroprotective effects of TA against environmental toxicant-induced neurotoxicity.
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