ArticleFrontiers in behavioral neuroscience2026
Same dose, different impact: acute cannabis intoxication impairs visuospatial working memory in both sexes, with disproportionate male vulnerability.
Article in Frontiers in behavioral neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Motion and form perception in healthy individuals with adolescent cannabis use.Frontiers in psychiatry · 2026Article
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9 authors.
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Abstract
Introduction: With expanding global cannabis legalization and rising usage rates, elucidating the specific neurocognitive impact of acute cannabis intoxication across biological sexes is critical. Methods: Using a 2 × 2 factorial design, we examined 154 adults: 77 individuals who use cannabis regularly (≥ 5 days/week for ≥ 1 year; 46 males, 31 females) and 77 matched controls (32 males, 45 females). Participants completed standardized Wechsler Memory Scale subtests assessing four distinct memory domains during the peak pharmacokinetic window (45 min post-consumption of medical-grade cannabis: 16.1% THC, < 1% CBD). Results: Results demonstrated notable neuropsychological specificity: visuospatial working memory was selectively impaired, whereas auditory-verbal and short-term memory domains remained completely intact-a pattern strongly implicating disruption of fronto-parietal networks rich in CB1 receptors. Crucially, a significant Group × Sex interaction, Discussion: These findings advance our understanding of cannabis neuropharmacology by demonstrating that cognitive vulnerability is both domain-specific and sex-dependent, with direct implications for precision medicine approaches to cannabis therapeutics and sex-informed harm reduction strategies.
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