ReviewThe Malaysian journal of medical sciences : MJMS2025
Congenital Cytomegalovirus Infection in Malaysia: A Scoping Review, Clinical Insights and Future Directions.
Review in The Malaysian journal of medical sciences : MJMS, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- Financing and health system capacity for precision medicine in Asia: a six country landscape analysis.Health affairs scholar · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Congenital cytomegalovirus (cCMV) infection is the most common congenital infection worldwide, greatly contributing to neonatal morbidity and long-term neurological and audiological complications. Despite its clinical burden, cCMV remains underdiagnosed in Malaysia due to the absence of routine screening programmes and limited awareness among healthcare professionals. This review presents an overview of the epidemiology, clinical manifestations, diagnostic approaches, and management strategies of cCMV in Malaysia, highlighting gaps in current practices and potential future approaches. The seroprevalence of cytomegalovirus (CMV) among pregnant women in Malaysia is high, with reported maternal seropositivity rates between 74% and 84%. However, cCMV incidence remains poorly defined due to the lack of systematic screening. Clinical features range from asymptomatic infection to severe neurodevelopmental impairments, sensorineural hearing loss, and visual deficits. Current diagnostic methods rely on polymerase chain reaction (PCR)-based detection of CMV DNA from urine, saliva, or blood within the first three weeks of life. However, access to molecular testing is limited. Treatment with antiviral agents such as valganciclovir can improve neurodevelopmental outcomes, particularly in symptomatic infants, but remains underutilised due to cost and availability constraints. Emerging research on rapid antigen-based diagnostics and maternal antiviral prophylaxis offers opportunities for improving early detection and intervention. Future strategies should focus on increasing awareness among healthcare providers, implementing targeted or universal newborn screening, and promoting research on cost-effective diagnostic and treatment modalities. Strengthening national policies and integrating cCMV management into existing maternal and child health programmes is vital to mitigate its long-term impact.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.