Evidence map›Paper›PMID 42077252›Full record

ArticleThe Malaysian journal of medical sciences : MJMS2025

SF1, a Standardised Fraction from

Faridah Ismail, Yusmazura Zakaria, Muhammad Lokman Md Isa, Nik Fakhuruddin Nik Hassan, Suat Cheng Tan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Malaysian journal of medical sciences : MJMS, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Faridah IsmailDepartment of Basic Medical Sciences, Kulliyyah of Medicine, International Islamic University Malaysia, Kuantan, Pahang, Malaysia.
Yusmazura ZakariaBiomedicine Programme, School of Health Sciences, Health Campus, Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia.
Muhammad Lokman Md IsaInstitute of Planetary Survival for Sustainable Well-being (PLANETIIUM), International Islamic University Malaysia, Kuantan, Pahang, Malaysia.
Nik Fakhuruddin Nik HassanForensic Science Programme, School of Health Sciences, Health Campus, Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia.
Suat Cheng TanBiomedicine Programme, School of Health Sciences, Health Campus, Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Aberrant activation of Notch1 signalling in Cervical Cancer Stem Cells (CCSCs) plays a key role in the disease development, progression, metastasis, recurrence, and chemoresistance. Thus, targeting Notch1 is crucial for CCSC eradication. SF1, a standardised fraction from Methods: SF1 was isolated from Results: The study discovered that SiHa cervospheres were efficient at forming spheres and contained more Sox2- and Nanog-positive cells than SiHa monolayers. In addition, cervospheres exhibited elevated Notch1 activity, with higher levels of the active Conclusion: SF1 possesses antitumor effects against SiHa-derived CCSCs via modulation of Notch1-signalling, a pathway associated with Cancer Stem Cells stemness.

Indexed as

cancer stem cellscervical cancerClinacanthus nutansNotch1 signallingstemness

Identifiers

PMID42077252
PMCPMC13132137

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.