Evidence map›Paper›PMID 42077170›Full record

ArticleACS infectious diseases2026

Computer-Aided Discovery of Small-Molecule Inhibitors of Pathogenic New World Arenavirus Entry and Replication.

Samantha Rae Wasson, Ben Matthew Flude, Martina Salerno, Kie Hoon Jung, Gilda Padalino, Salvatore Ferla, Dylan Joseph Roche-Dugmore, Connor W Bott, Andrea Brancale, Brian B Gowen and 1 more

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Article in ACS infectious diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Samantha Rae WassonInstitute for Antiviral Research, Utah State University, Logan, Utah84322, United States.
Ben Matthew FludeDepartment of Chemistry, College of Science and Engineering, Swansea University, SwanseaSA2 8PP, U.K.
Martina SalernoDepartment of Chemistry, College of Science and Engineering, Swansea University, SwanseaSA2 8PP, U.K.
Kie Hoon JungInstitute for Antiviral Research, Utah State University, Logan, Utah84322, United States.
Gilda PadalinoMedical School, Faculty of Medicine, Health and Life Science, Swansea University, SwanseaSA2 8PP, U.K.ORCID 0000-0001-8580-1293
Salvatore FerlaMedical School, Faculty of Medicine, Health and Life Science, Swansea University, SwanseaSA2 8PP, U.K.
Dylan Joseph Roche-DugmoreDepartment of Chemistry, College of Science and Engineering, Swansea University, SwanseaSA2 8PP, U.K.
Connor W BottDepartment of Chemistry, College of Science and Engineering, Swansea University, SwanseaSA2 8PP, U.K.
Andrea BrancaleDepartment of Organic Chemistry, University of Chemistry and Technology, Prague, Prague16628, Czech Republic.ORCID 0000-0002-9728-3419
Brian B GowenInstitute for Antiviral Research, Utah State University, Logan, Utah84322, United States.
Marcella BassettoDepartment of Chemistry, College of Science and Engineering, Swansea University, SwanseaSA2 8PP, U.K.ORCID 0000-0002-2491-5868

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pathogenic New World arenaviruses (NWAs), including Junín (JUNV) and Machupo (MACV) viruses, rely on host-virus entry processes that represent attractive points for antiviral intervention. Guided by the known use of human transferrin receptor 1 (hTfR1) by several NWAs for cell entry, we conducted a structure-based virtual screening campaign targeting the MACV GP1-hTfR1 interaction interface to identify small molecules capable of inhibiting early infection. From an

Indexed as

Antiviral AgentsArenaviruses, New WorldDrug DiscoverySmall Molecule LibrariesVirus InternalizationVirus ReplicationAnimalsAntigens, CDArenaviridae InfectionsHumansMiceReceptors, TransferrinAntigens, CDAntiviral AgentsCD71 antigenReceptors, TransferrinSmall Molecule Librariescomputer-aided drug design (CADD)medicinal chemistryNew World arenavirusessmall-molecule antiviralstransferrin receptor 1 (TfR1)

Identifiers

PMID42077170
PMCPMC13270517

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.