Evidence map›Paper›PMID 42077068›Full record

ArticleCell adhesion & migration2026

CXCL11 secreted by cancer-associated fibroblasts promotes nasopharyngeal carcinoma progression via CXCR3/PD-L1 axis.

Jie Fang, Huijuan Cheng, Peng Zhang, Liang Wang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell adhesion & migration, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Jie FangDepartment of Head and Neck Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan Province, China.
Huijuan ChengDepartment of Head and Neck Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan Province, China.
Peng ZhangDepartment of Head and Neck Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan Province, China.
Liang WangDepartment of Head and Neck Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan Province, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The secretion of chemokines by cancer-associated fibroblasts (CAFs) is a critical driver of cancer progression. Nevertheless, the precise contribution of CAFs in the nasopharyngeal carcinoma (NPC) tumor microenvironment to disease progression is yet to be fully understood. In this study, C-X-C motif chemokine ligand 11 (CXCL11) was identified to be upregulated in tumor tissues of NPC patients and NPC cells compared to counterpart normal tissues and cell lines. The CAFs-secreted CXCL11 was found to enhance the proliferative, invasive, and migratory capacities of NPC cells. CAFs-derived CXCL11 upregulates CXCR3 expression to facilitate NPC cell proliferation, migration, and invasion. Through mechanism investigation, we confirmed that CXCL11/CXCR3 axis upregulated PD-L1 expression through p65-mediated transcription activation. Finally,

Indexed as

B7-H1 AntigenCancer-Associated FibroblastsChemokine CXCL11Nasopharyngeal CarcinomaNasopharyngeal NeoplasmsReceptors, CXCR3AnimalsCell Line, TumorCell MovementCell ProliferationDisease ProgressionGene Expression Regulation, NeoplasticHumansMiceMice, NudeSignal TransductionB7-H1 AntigenCD274 protein, humanChemokine CXCL11CXCL11 protein, humanCXCR3 protein, humanReceptors, CXCR3Cancer-associated fibroblastsCXCL11CXCR3nasopharyngeal carcinomaPD-L1

Identifiers

PMID42077068
PMCPMC13155017

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.