Evidence map›Paper›PMID 42077048›Full record

ArticleJournal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale

Altered ABR Waveform Patterns in Tinnitus Patients With Normal Full-Frequency Hearing May Be Induced by Abnormal Middle Ear Muscle Activity Via the Trigeminal Nerve System.

Yun Jiang, Tianyi Ni, Hongbo Xie, Siyi Yang, Ziyuan Lin, Jian Ruan, Min Zhang, Xiuling Lu, Wenjing Zhang, Wenjing Su and 2 more

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Article in Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

12 authors.

Yun JiangDepartment of Otorhinolaryngology-Head & Neck Surgery, Huadong Hospital affiliated Fudan University, Shanghai, China.
Tianyi NiDepartment of Otorhinolaryngology-Head & Neck Surgery, Huadong Hospital affiliated Fudan University, Shanghai, China.
Hongbo XieDepartment of Otorhinolaryngology-Head & Neck Surgery, Huadong Hospital affiliated Fudan University, Shanghai, China.
Siyi YangDepartment of Otorhinolaryngology-Head & Neck Surgery, Huadong Hospital affiliated Fudan University, Shanghai, China.
Ziyuan LinDepartment of Otorhinolaryngology-Head & Neck Surgery, Huadong Hospital affiliated Fudan University, Shanghai, China.
Jian RuanDepartment of Otorhinolaryngology-Head & Neck Surgery, Huadong Hospital affiliated Fudan University, Shanghai, China.
Min ZhangShanghai Key Laboratory of Clinical Geriatrics, Huadong Hospital, and Research Center of Aging and Medicine, Shanghai Medical College, Fudan University, Shanghai, China.
Xiuling LuDepartment of Otorhinolaryngology-Head & Neck Surgery, Huadong Hospital affiliated Fudan University, Shanghai, China.
Wenjing ZhangDepartment of Otorhinolaryngology-Head & Neck Surgery, Huadong Hospital affiliated Fudan University, Shanghai, China.
Wenjing SuDepartment of Otorhinolaryngology-Head & Neck Surgery, Huadong Hospital affiliated Fudan University, Shanghai, China.
Yuehong LiuDepartment of Otorhinolaryngology-Head & Neck Surgery, Huadong Hospital affiliated Fudan University, Shanghai, China.ORCID 0000-0002-6816-4322
Zhao HanDepartment of Otorhinolaryngology-Head & Neck Surgery, Huadong Hospital affiliated Fudan University, Shanghai, China.ORCID 0000-0002-5753-6952

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

ImportanceEvidence regarding the mechanism of tinnitus in patients with normal full-frequency hearing remains limited. This study investigated the auditory brainstem response (ABR) waveform patterns in these patients to address this unmet need, which is of considerable assistance in the clinical management of tinnitus with normal hearing.ObjectiveThis study aims to investigate the potential underlying mechanisms of tinnitus with normal full-frequency (125 Hz-16 kHz) hearing threshold by analyzing waveform alterations in ABR among tinnitus patients.DesignCross-sectional study.SettingOtolaryngology outpatient of a tertiary referral hospital.ParticipantsPatients aged 20 to 40 years with unilateral subjective tinnitus and normal hearing (pure-tone thresholds ≤25 dB HL across 0.125-16 kHz) were recruited. Age-matched healthy volunteers with normal full-frequency hearing (0.125-16 kHz) and without tinnitus served as controls.ExposuresParticipants were categorized according to the presence of unilateral subjective tinnitus.Main Outcome MeasuresThe primary outcomes included pure-tone audiometry testing (0.125-16 kHz) and ABR testing using 80 dB nHL click stimuli with alternating polarity (19.9 Hz, 1024 scans).ResultsThe study included 136 adult subjects with normal hearing at all frequencies, including 60 unilateral tinnitus patients and 76 normal volunteers. Results showed no significant differences in ABR waveform characteristics between affected and unaffected ears in unilateral tinnitus patients ((

Indexed as

Ear, MiddleEvoked Potentials, Auditory, Brain StemTinnitusTrigeminal NerveAdultAudiometry, Pure-ToneAuditory AcuityAuditory ThresholdCase-Control StudiesCross-Sectional StudiesFemaleHumansMaleYoung Adultauditory brainstem responseextended high-frequencymiddle ear musclenormal full-frequency hearingserotonin systemtinnitustrigeminal nerve system

Identifiers

PMID42077048
PMCPMC13157550

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.