Evidence map›Paper›PMID 42076928›Full record

ArticleHead & neck2026

Impact of Smoking on Treatment Outcomes in Patients With Human Papillomavirus-Related Oropharyngeal Cancer.

Michelle M Kwan, Latifa A Bazzi, Zequn Sun, Dayton Rand, Asher Park, Shravan Asthana, Alexis Larson, Poonam Yadav, Bharat B Mittal, Adil Akthar and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Head & neck, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Michelle M KwanFeinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.
Latifa A BazziDivision of Biostatistics and Informatics, Department of Preventive Medicine, Northwestern University, Chicago, Illinois, USA.
Zequn SunDivision of Biostatistics and Informatics, Department of Preventive Medicine, Northwestern University, Chicago, Illinois, USA.ORCID https://orcid.org/0000-0001-9301-6295
Dayton RandDepartment of Otolaryngology, Northwestern University, Chicago, Illinois, USA.
Asher ParkFeinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.ORCID https://orcid.org/0000-0002-3631-463X
Shravan AsthanaFeinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.ORCID https://orcid.org/0000-0002-1356-3764
Alexis LarsonDepartment of Otolaryngology, Northwestern University, Chicago, Illinois, USA.
Poonam YadavDepartment of Radiation Oncology, Northwestern University, Chicago, Illinois, USA.
Bharat B MittalDepartment of Radiation Oncology, Northwestern University, Chicago, Illinois, USA.ORCID https://orcid.org/0000-0002-6541-8753
Adil AktharDepartment of Radiation Oncology, Northwestern University, Chicago, Illinois, USA.
Sarah KramerDepartment of Otolaryngology, Northwestern University, Chicago, Illinois, USA.
Jochen H LorchDivision of Hematology and Oncology, Department of Medicine, Northwestern University, Chicago, Illinois, USA.
Sandeep SamantDepartment of Otolaryngology, Northwestern University, Chicago, Illinois, USA.
Urjeet PatelDepartment of Otolaryngology, Northwestern University, Chicago, Illinois, USA.
Michelle L MierzwaDepartment of Radiation Oncology, University of Michigan, Ann Arbor, Michigan, USA.ORCID https://orcid.org/0000-0002-3923-9970
Leila J MadyDepartment of Otolaryngology, Johns Hopkins University, Baltimore, Maryland, USA.ORCID https://orcid.org/0000-0002-2682-3297
Katelyn O StepanDepartment of Otolaryngology, Northwestern University, Chicago, Illinois, USA.
Laila A GharzaiDepartment of Radiation Oncology, Northwestern University, Chicago, Illinois, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPatients with HPV+ oropharyngeal cancer (OPC) have worse outcomes with longer smoking history (≥ 10 pack-years). This has been confirmed in trials of primary radiotherapy but not surgery, suggesting differential smoking impact by treatment received. We assessed smoking-related outcomes at a single institution.

methodsKaplan-Meier and Cox proportional hazards regression compared < 10 versus ≥ 10 pack-years by treatment received for progression-free survival (PFS) and overall survival (OS).

resultsSmoking was associated with worse PFS in both primary (chemo)radiation (HR = 1.73 [1.12-2.69], p = 0.01) and primary surgery cohorts (HR = 1.77 [1.02-3.07], p = 0.04). In surgery patients, this association was attenuated after adjusting for socioeconomic indicators (HR = 1.69 [0.97-2.93], p = 0.06). On recursive partitioning analysis, ≥ 25 pack-years was associated with worse PFS and OS overall and among radiotherapy patients.

conclusionsSmoking impacts outcomes in HPV + OPC regardless of treatment modality. Treatment-specific differences in prior randomized studies may reflect underlying differences in patient characteristics. ≥ 25 pack-years was associated with worse outcomes.

Indexed as

Oropharyngeal NeoplasmsPapillomavirus InfectionsSmokingAgedFemaleHuman Papillomavirus VirusesHumansKaplan-Meier EstimateMaleMiddle AgedProgression-Free SurvivalProportional Hazards ModelsRetrospective StudiesTreatment Outcomede‐escalationhuman papillomavirusoropharyngeal cancersmoking historysocioeconomic status

Identifiers

PMID42076928
PMCPMC13595481

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.