Evidence map›Paper›PMID 42076917›Full record

ArticleJournal of clinical periodontology2026

Exploring the Potential of the PerioAI System to Support Periodontal Clinical Decision Making: A Proof-of-Principle Study.

Hairui Li, Yuan Li, Minhui Tan, Zhiming Cui, Dinggang Shen, Andrea Roccuzzo, Maurizio S Tonetti

Abstract read
In one paragraph

Article in Journal of clinical periodontology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Hairui LiShanghai Perio-Implant Innovation Center and Oral Biomedical Intelligence Technology Laboratory (ORAL-BIT Lab), Institute of Integrated Oral, Craniofacial and Sensory Research, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.ORCID https://orcid.org/0000-0001-6592-7876
Yuan LiShanghai Perio-Implant Innovation Center and Oral Biomedical Intelligence Technology Laboratory (ORAL-BIT Lab), Institute of Integrated Oral, Craniofacial and Sensory Research, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.ORCID https://orcid.org/0000-0002-0133-7516
Minhui TanSchool of Biomedical Engineering & State Key Laboratory of Advanced Medical Materials and Devices, ShanghaiTech University, Shanghai, China.
Zhiming CuiSchool of Biomedical Engineering & State Key Laboratory of Advanced Medical Materials and Devices, ShanghaiTech University, Shanghai, China.
Dinggang ShenSchool of Biomedical Engineering & State Key Laboratory of Advanced Medical Materials and Devices, ShanghaiTech University, Shanghai, China.
Andrea RoccuzzoShanghai Perio-Implant Innovation Center and Oral Biomedical Intelligence Technology Laboratory (ORAL-BIT Lab), Institute of Integrated Oral, Craniofacial and Sensory Research, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Maurizio S TonettiShanghai Perio-Implant Innovation Center and Oral Biomedical Intelligence Technology Laboratory (ORAL-BIT Lab), Institute of Integrated Oral, Craniofacial and Sensory Research, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.ORCID https://orcid.org/0000-0002-2743-0137

Funding

Cross-Disciplinary Research Fund of Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine JYJC202135National Natural Science Foundation of China 62131015National Natural Science Foundation of China 6230012077National Natural Science Foundation of China 62476033National Natural Science Foundation of China 82301157National Natural Science Foundation of China U23A20295
6 · The paper itself

Abstract

aimTo explore the potential of PerioAI, an artificial intelligence system integrating intraoral scanning and cone-beam CT, to automatically measure gingival margin-to-bone distance (GBD) and convert it into AI-derived probing depth (AI-PD), and to evaluate whether AI-PD may provide additional information to support periodontal clinical decision making when radiographic imaging represents the primary source of available periodontal information. MATERIALS AND

methodsThis cross-sectional proof-of-principle study included 53 patients with periodontitis (1298 teeth, 7788 sites). GBD measurements were converted to AI-PD using validated formulas. Clinical decision making (prognosis and treatment planning) was evaluated by one periodontist under three information conditions: (i) orthopantomogram (OPG) + original periodontal chart (used to establish the reference clinical decision); (ii) OPG-only; and (iii) OPG + AI-PD. Using the reference clinical decision, agreement rates for clinical decisions obtained under the two information conditions (OPG-only and OPG + AI-PD) were calculated and compared, and the risk of overtreatment was also assessed.

resultsCompared with OPG-only, the OPG + AI-PD condition showed higher agreement rate with the reference clinical decision, indicating that PerioAI may provide additional information for clinical decision making. Patient-level average agreement rates increased from 77.6% to 84.7% for prognosis (p < 0.05) and from 78.2% to 84.3% for treatment planning (p < 0.05). Tooth-level agreement rates improved from 78.1% to 86.0% for prognosis (p < 0.05) and from 78.8% to 85.4% for treatment planning (p < 0.05). The addition of AI-PD was associated with a 42.3% reduction in overtreatment risk (Steps 1-2 vs. Step 3) and a 98.5% reduction in the risk of tooth extraction (Step 3 vs. extraction).

conclusionsWhen combined with radiographic information, PerioAI shows potential to provide incremental information for clinical decision making. Future research should integrate additional periodontal parameters and validate the approach in larger and more diverse populations.

Indexed as

Clinical Decision-MakingIntelligent SystemsPeriodontitisAdultAgedCone-Beam Computed TomographyCross-Sectional StudiesFemaleGingivaHumansMaleMiddle AgedPatient Care PlanningPeriodontal PocketPrognosisProof of Concept Studyartificial intelligenceclinical trialperiodontal prognosisperiodontal treatment plan

Identifiers

PMID42076917
PMCPMC13263713

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.