Evidence map›Paper›PMID 42076813›Full record

ArticleElectrophoresis2026

Validated RP-HPLC-UV Method for the Quantitative Analysis and Stability Evaluation of Amoxicillin in Paediatric Gummy Tablets.

Samuele Bonafè, Anna Imbriano, Cinzia Pagano, Anna Migni, Elisa Bianconi, Laura Mercolini, Luana Perioli, Roccaldo Sardella

Abstract read
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In one paragraph

Article in Electrophoresis, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Samuele BonafèDepartment of Pharmaceutical Sciences, University of Perugia, Perugia, Italy.
Anna ImbrianoDepartment of Pharmaceutical Sciences, University of Perugia, Perugia, Italy.
Cinzia PaganoDepartment of Pharmaceutical Sciences, University of Perugia, Perugia, Italy.
Anna MigniDepartment of Pharmaceutical Sciences, University of Perugia, Perugia, Italy.
Elisa BianconiDepartment of Pharmaceutical Sciences, University of Perugia, Perugia, Italy.
Laura MercoliniDepartment of Pharmacy and Biotechnology (FaBiT), Alma Mater Studiorum, University of Bologna, Bologna, Italy.
Luana PerioliDepartment of Pharmaceutical Sciences, University of Perugia, Perugia, Italy.
Roccaldo SardellaDepartment of Pharmaceutical Sciences, University of Perugia, Perugia, Italy.

Funding

European Union-Next Generation EU under the Italian Ministry of University and Research (MUR) National Innovation Ecosystem ECS00000041-Next Generation EU under the Italian Ministry of University and Research (MUR) National Innovation Ecosystem J97G22000170005
6 · The paper itself

Abstract

The development of products that encounter compliance from paediatric patients represents one of the challenges of pharmaceutical technology that aims to develop formulations able to overcome problems related to palatability and dosing flexibility and, in general, to patient acceptance. In this study, a fully validated reversed-phase high-performance liquid chromatography coupled with ultraviolet detection (RP-HPLC-UV) method was applied for the quantitative determination of amoxicillin (AMX) in an innovative gummy tablet formulation designed for paediatric use. The chromatographic method was optimized and validated largely (but not strictly) in accordance with ICH Q2(R1) guidelines, evaluating specificity, linearity, limit of quantification (LOQ), trueness, precision, robustness and ruggedness. A blank matrix derived from a blank formulation was employed to closely simulate the sample matrix during method validation and quantitative analysis. The method exhibited excellent linearity over the concentration range of 0.0039-0.25 mg/mL (R

Indexed as

AmoxicillinChromatography, Reverse-PhaseChromatography, High Pressure LiquidDrug StabilityLimit of DetectionLinear ModelsReproducibility of ResultsSpectrophotometry, UltravioletTabletsAmoxicillinTabletsamoxicillingummy tabletsmethod validationpaediatric dosage formreversed‐phase high‐performance liquid chromatography coupled with ultraviolet (RP‐HPLC–UV)stability study

Identifiers

PMID42076813
PMCPMC13378233

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.