The Very Virulent IBDV Viral Protein VP3 Promotes the Caspase-3 Mediated Cleavage of GSDME.

Tao Zhang, Suyan Wang, Xiaole Qi, Lijie Tang, Yulong Gao

Abstract read

In one paragraph

Article in Veterinary sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Tao ZhangState Key Laboratory for Animal Disease Control and Prevention, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150069, China.

Suyan WangState Key Laboratory for Animal Disease Control and Prevention, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150069, China.

Xiaole QiState Key Laboratory for Animal Disease Control and Prevention, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150069, China.

Lijie TangCollege of Veterinary Medicine, Northeast Agricultural University, Changjiang Road No. 600, Xiang Fang District, Harbin 150069, China.

Yulong GaoState Key Laboratory for Animal Disease Control and Prevention, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150069, China.ORCID 0000-0002-0448-8467

Funding

China Agriculture Research System (CARS-41) and Innovation program of Chinese Academy of Agricultural science CAAS-CSLPDCP-202402Heilongjiang Provincial Natural Science Foundation of China YQ2023C029National Key Research and Development Program of China 2023YFE0106100National Natural Science Foundation of China 32473000

6 · The paper itself

Abstract

The infectious bursal disease virus (IBDV) can cause severe immunosuppression and high mortality in chickens, posing a significant threat to the poultry farming industry. Pyroptosis mediated by gasdermin E (GSDME) may be closely related to the tissue damage caused by IBDV. In this study, 3-week-old specific-pathogen-free (SPF) White Leghorns chickens were inoculated intranasally with 1000 copies/200 μL of very virulent IBDV (vvIBDV) Gx strain, and we analyzed GSDME expression in chicken tissues and the cleavage site of GSDME by Caspase-3. Tissue distribution results showed that GSDME and IL-1β transcription in the bursa of Fabricius and kidneys were significantly upregulated by more than five-fold (

Indexed as

GSDMEIBDVpyroptosis

Identifiers

PMID42076745

DOI10.3390/vetsci13040373

PMCPMC13120087

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.