ArticleVeterinary sciences2026
The Dry Secretion Metabolome: LC-MS Profiling Distinguishes Subclinical Mastitis from Healthy Udder Quarters Across the Dry Period in Dairy Cows.
Article in Veterinary sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
The dry period is a critical window of susceptibility to intramammary infection in dairy cows, yet the metabolic environment of the mammary gland during this phase remains largely uncharacterized. The objective of this study was to profile the metabolome of bovine dry secretion fluid from quarters with subclinical mastitis (SCM; SCC ≥ 200,000 cells/mL) and healthy quarters (H; SCC < 200,000 cells/mL) on day 2 (D2) and day 21 (D21) of the dry period (n = 10 per group quarters per group, drawn from a cohort of 41 enrolled Holstein dairy cows) using high-performance chemical isotope labeling liquid chromatography-mass spectrometry (CIL-LC-MS). A total of 474 metabolites were positively identified. At D2, 186 metabolites differed significantly between SCM and H quarters, with dipeptides dominating the upregulated metabolites, indicating active proteolysis in infected quarters. Norepinephrine was the most significantly depleted metabolite (FC = 0.27,
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