Evidence map›Paper›PMID 42076343›Full record

ArticlePolymers2026

Electrospun Multilayer Scaffolds Based on Poly (L-Lactic Acid) and Poly (Acrylonitrile) Reinforced with CaO Nanoparticles for Enhanced Skin Regeneration and Wound Healing.

Eugenio Rivera, Lissette Montoille, Fabián Guajardo, Fabian Álvarez-Carrasco, Sebastián Romero, Mauricio Gómez-Barrena, Esmeralda Lopez, Carlos Loyo, Claudio García-Herrera, Paula A Zapata and 3 more

Abstract read
In one paragraph

Article in Polymers, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Eugenio RiveraLaboratorio de Biomecánica y Biomateriales, Departamento de Ingeniería Mecánica, Facultad de Ingeniería, Universidad de Santiago de Chile, Santiago 9170022, Chile.ORCID 0000-0001-8103-2706
Lissette MontoilleLaboratorio de Biomecánica y Biomateriales, Departamento de Ingeniería Mecánica, Facultad de Ingeniería, Universidad de Santiago de Chile, Santiago 9170022, Chile.
Fabián GuajardoInstituto de Ciencias Naturales, Facultad de Medicina Veterinaria y Agronomía, Universidad de Las Américas, Manuel Montt 948, Santiago 7500975, Chile.
Fabian Álvarez-CarrascoLaboratorio de Biomecánica y Biomateriales, Departamento de Ingeniería Mecánica, Facultad de Ingeniería, Universidad de Santiago de Chile, Santiago 9170022, Chile.ORCID 0009-0000-2506-4623
Sebastián RomeroInstituto de Ciencias Naturales, Facultad de Medicina Veterinaria y Agronomía, Universidad de Las Américas, Manuel Montt 948, Santiago 7500975, Chile.
Mauricio Gómez-BarrenaCentro de Investigación y Desarrollo en Ciencias de la Ingeniería (CIDCI), Escuela de Ingeniería Civil y Ciencias Geoespaciales, Facultad de Ingeniería Ciencia y Tecnología, Universidad Bernardo O'Higgins, Av. Viel 1497, Santiago 8370993, Chile.ORCID 0000-0003-2010-5910
Esmeralda LopezGrupo Polímeros, Departamento de Ciencias del Ambiente, Facultad de Química y Biología, Universidad de Santiago de Chile (USACH), Casilla 40, Correo 33, Santiago 9170022, Chile.ORCID 0000-0001-5540-7199
Carlos LoyoSchool of Chemical Sciences and Engineering, Yachay Tech University, Hda. San José s/n y Proyecto Yachay, Urcuquí 100119, Ecuador.
Claudio García-HerreraFacultad de Ingeniería y Ciencias, Universidad Adolfo Ibañez UAI, Diagonal Las Torres 2640, Santiago 7941169, Chile.ORCID 0000-0002-1283-8551
Paula A ZapataGrupo Polímeros, Departamento de Ciencias del Ambiente, Facultad de Química y Biología, Universidad de Santiago de Chile (USACH), Casilla 40, Correo 33, Santiago 9170022, Chile.ORCID 0000-0003-3361-6226
Diana Zárate-TriviñoLaboratorio de Inmunología y Virología, Facultad de Ciencias Biológicas, Universidad Autónoma de Nuevo León, San Nicolás de los Garza 66455, Mexico.ORCID 0000-0002-0852-8948
Juan José MartinezCentro de Ingeniería y Desarrollo Industrial, Av. Playa Pie de la Cuesta No.702, Desarrollo San Pablo, Santiago de Querétaro 76125, Mexico.
Daniel A CanalesInstituto de Ciencias Naturales, Facultad de Medicina Veterinaria y Agronomía, Universidad de Las Américas, Manuel Montt 948, Santiago 7500975, Chile.ORCID 0000-0002-2691-6864

Funding

Agencia Nacional de Investigación y Desarrollo PFCHA/DOCTORADO NACIONAL BECAS CHILE 2023-21231931Fondo Nacional de Desarrollo Científico y Tecnológico FONDECYT INITIATION PROJECT N°11241496Vicerrectoría de Investigación, Innovación y Creación. Universidad de Santiago de Chile JUV_INVESTIGADORA_DICYT_USA21991, Código 052416RM_JUVI
6 · The paper itself

Abstract

This study reports the development and characterization of hierarchical electrospun scaffolds based on poly (L-lactic acid) (PLA) and polyacrylonitrile (PAN) reinforced with calcium oxide (CaO) nanoparticles (18.5 ± 4.7 nm) for skin regeneration. Six configurations, including two five-layer multilayer systems (PLA/PAN/CaO and PAN/PLA/CaO), were evaluated to determine how composition and deposition sequence influence physicochemical, mechanical, and biological performance. FT-IR, XRD and DSC confirmed the successful integration of CaO, while thermal analysis evidenced an effect of chain mobility and interfacial interactions within multilayer systems. Cross-sectional SEM revealed the presence of both fibers with continuous interfaces. Nitrogen adsorption showed that CaO significantly increased the specific surface area (e.g., from 4.6 m

Indexed as

CaO nanoparticleselectrospun matricesmultilayer architecturesPLA/PAN blendsskin tissue regeneration

Identifiers

PMID42076343
PMCPMC13120193

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.