ArticleMicromachines2026
Development of a Highly Sensitive SPR Biosensor for BCR-ABL Gene Sequence Detection Using a Novel Gold Nanoparticle-Enhanced Sandwich Assay Format.
Article in Micromachines, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
SPR (surface plasmon resonance) biosensor-based analytical methods enable rapid, straightforward, and cost-effective detection of DNA oligonucleotides. However, the detection limits of currently available SPR biosensors for BCR-ABL gene oligonucleotides remain too high to reliably detect sub-nanomolar concentrations. This study presents a new signal-enhancement approach for SPR DNA biosensors based on a gold nanoparticle (AuNP) sandwich assay. In this work, we demonstrated that AuNP-modified oligonucleotides can serve as labels that significantly amplify the SPR biosensor response in a sandwich-type SPR DNA biosensor. The analytical characteristics of the developed AuNP-labeled biosensor for detection of BCR-ABL fusion gene oligonucleotides were studied. The AuNP-labeled biosensor exhibited a detection limit of 80 pM, which is significantly lower than that of a traditional label-free SPR biosensor (50 nM). The measurement error for BCR-ABL target detection was significantly lower with the AuNP-labeled biosensor than with the label-free SPR biosensor. The conditions of synthesis of AuNPs by citrate reduction of AuCl
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