ArticlePharmaceutics2026
Synthesis of 4-Hydroxyphenylamino-Naphthoquinones as Paracetamol-Inspired Analogs: Chemical, In Silico, and Phenotypic Pharmacological Evaluation.
Iván M Quispe-Díaz, Oswaldo Rebaza-Rioja, Sussan Lopez-Mercado, Cinthya Enriquez-Lara, Daniel Asunción-Alvarez, Roberto O Ybañez-Julca, Elena Mantilla-Rodríguez, Wilfredo O Gutiérrez-Alvarado, Ricardo Pino-Rios, Jaime A Valderrama and 1 more
Abstract read
In one paragraphArticle in Pharmaceutics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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2 · The registryThe trial behind it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
11 authors.
Iván M Quispe-DíazFacultad de Farmacia y Bioquímica, Universidad Nacional de Trujillo, Trujillo 13011, Peru.ORCID 0000-0001-8515-0654 Oswaldo Rebaza-RiojaFacultad de Farmacia y Bioquímica, Universidad Nacional de Trujillo, Trujillo 13011, Peru.
Sussan Lopez-MercadoLaboratorio de Química Medicinal, Química y Farmacia, Facultad de Ciencias de la Salud, Universidad Arturo Prat, Casilla 121, Iquique 1100000, Chile.
Cinthya Enriquez-LaraPrograma de Doctorado en Química Medicinal, Facultad de Ciencias de la Salud, Universidad Arturo Prat, Casilla 121, Iquique 1100000, Chile.ORCID 0000-0002-9839-7389 Daniel Asunción-AlvarezFacultad de Farmacia y Bioquímica, Universidad Nacional de Trujillo, Trujillo 13011, Peru.ORCID 0000-0001-7498-2121 Roberto O Ybañez-JulcaFacultad de Farmacia y Bioquímica, Universidad Nacional de Trujillo, Trujillo 13011, Peru.ORCID 0000-0003-0011-7957 Elena Mantilla-RodríguezFacultad de Farmacia y Bioquímica, Universidad Nacional de Trujillo, Trujillo 13011, Peru.
Wilfredo O Gutiérrez-AlvaradoFacultad de Farmacia y Bioquímica, Universidad Nacional de la Amazonía Peruana, Iquitos 16001, Peru.ORCID 0000-0002-1240-7612 Ricardo Pino-RiosDepartamento de Ciencias Químicas, Facultad de Ciencias Exactas, Universidad Andrés Bello, Santiago 8370146, Chile.ORCID 0000-0003-4756-1115 Jaime A ValderramaLaboratorio de Química Medicinal, Química y Farmacia, Facultad de Ciencias de la Salud, Universidad Arturo Prat, Casilla 121, Iquique 1100000, Chile.
Julio BenitesLaboratorio de Química Medicinal, Química y Farmacia, Facultad de Ciencias de la Salud, Universidad Arturo Prat, Casilla 121, Iquique 1100000, Chile.ORCID 0000-0002-8562-0078 Funding
Fondo Interno VRII-UNAP, Chile grant number VRIIP0056-21Proyecto PROCIENCIA , Peru PE. N◦ 01089273-2024
6 · The paper itselfAbstract
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Indexed as
4-hydroxyphenylamino-naphthoquinonesantinociceptive activityinflammatory painparacetamol-inspired analogsphenotypic pharmacologysolvent-free synthesis
Identifiers
PMID42076133
PMCPMC13119072
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