Evidence map›Paper›PMID 42076124›Full record

ArticlePharmaceutics2026

Thioester-Containing Ionizable Lipids with Enhanced Endosomal Escape and Biodegradability for mRNA and tRNA Delivery.

Álvaro Peña, Esther Broset, Enrique Lucia, Laura García-Latorre, Víctor Navarro, Carlos Matute, Ana Gallego-Lleyda, Teresa Alejo, Eduardo Romanos, Alba García and 2 more

Abstract read
In one paragraph

Article in Pharmaceutics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Álvaro PeñaCertest Pharma, Certest Biotec S. L., San Mateo de Gállego, 50840 Zaragoza, Spain.ORCID 0000-0002-3517-4102
Esther BrosetCertest Pharma, Certest Biotec S. L., San Mateo de Gállego, 50840 Zaragoza, Spain.ORCID 0000-0003-4155-749X
Enrique LuciaCertest Pharma, Certest Biotec S. L., San Mateo de Gállego, 50840 Zaragoza, Spain.
Laura García-LatorreCertest Pharma, Certest Biotec S. L., San Mateo de Gállego, 50840 Zaragoza, Spain.ORCID 0009-0005-7217-0038
Víctor NavarroCertest Pharma, Certest Biotec S. L., San Mateo de Gállego, 50840 Zaragoza, Spain.
Carlos MatuteCertest Pharma, Certest Biotec S. L., San Mateo de Gállego, 50840 Zaragoza, Spain.
Ana Gallego-LleydaCertest Pharma, Certest Biotec S. L., San Mateo de Gállego, 50840 Zaragoza, Spain.
Teresa AlejoCertest Pharma, Certest Biotec S. L., San Mateo de Gállego, 50840 Zaragoza, Spain.ORCID 0000-0002-9324-0446
Eduardo RomanosMedical Imaging and Phenotyping Core Facility, Aragon Health Sciences Institute (IACS), 50009 Zaragoza, Spain.ORCID 0000-0002-9918-3374
Alba GarcíaMedical Imaging and Phenotyping Core Facility, Aragon Health Sciences Institute (IACS), 50009 Zaragoza, Spain.ORCID 0009-0000-9760-5433
Juan Martínez-OlivánCertest Pharma, Certest Biotec S. L., San Mateo de Gállego, 50840 Zaragoza, Spain.
Javier Giménez-WarrenCertest Pharma, Certest Biotec S. L., San Mateo de Gállego, 50840 Zaragoza, Spain.

Funding

Gobierno de Aragón IDMF/2021/0009Ministerio de Ciencia, Innovación y Universidades 10.13039/501100011033
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

biodegradablelipid nanoparticles (LNPs)RNAthioester ionizable lipidstRNA

Identifiers

PMID42076124
PMCPMC13118925

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.