Evidence map›Paper›PMID 42076053›Full record

ArticlePharmaceutics2026

TIM-1 and Tiny-TIM as Robust In Vitro Models for Oral Biopharmaceutics: Evidence from an International Ring Study.

Connor O'Farrell, Robert Havenaar, Mark McAllister, Bart Hens, Richard Barker, Álvaro López Mármol, Andrea Ansari, Tom Ooms, Ronald Schilderink, Robert Schwabe and 10 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmaceutics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Connor O'FarrellInnoGI Technologies, Thijsseweg 11, 2629 JA Delft, The Netherlands.ORCID 0000-0002-4888-8892
Robert HavenaarNetherlands Organisation for Applied Scientific Research (TNO), Utrechtseweg 48, 3704 HE Zeist, The Netherlands.
Mark McAllisterDrug Product Design, Pfizer, Discovery Park, Ramsgate Road, Sandwich CT13 9ND, UK.
Bart HensDrug Product Design, Pfizer, Discovery Park, Ramsgate Road, Sandwich CT13 9ND, UK.ORCID 0000-0002-4229-9843
Richard BarkerGlobal Product Development, Pharmaceutical Technology & Development, Operations, AstraZeneca, Macclesfield SK10 2NA, UK.ORCID 0009-0004-2045-2028
Álvaro López MármolSynthetic Molecules CMC R&D, AbbVie Deutschland GmbH & Co. KG, Knollstrasse, 67061 Ludwigshafen, Germany.
Andrea AnsariSynthetic Molecules CMC R&D, AbbVie Deutschland GmbH & Co. KG, Knollstrasse, 67061 Ludwigshafen, Germany.
Tom OomsJohnson & Johnson, Turnhoutseweg 30, 2340 Beerse, Belgium.
Ronald SchilderinkNetherlands Organisation for Applied Scientific Research (TNO), Utrechtseweg 48, 3704 HE Zeist, The Netherlands.ORCID 0009-0000-1175-6792
Robert SchwabeMaterial and Analytical Sciences, Research and Development, Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, CT 06877, USA.ORCID 0000-0001-6732-7559
James ButlerGlaxoSmithKline R&D, Harris's Lane, Ware SG12 0DX, UK.ORCID 0000-0003-0126-967X
Malgorzata StróžykPozLab Sp. z o.o. Grupa Selvita, 6 Kobaltowa Str., 62-002 Zlotniki, Poland.
Tânia Martins GarciaInnoGI Technologies, Thijsseweg 11, 2629 JA Delft, The Netherlands.ORCID 0000-0003-2425-5967
Dyko MinekusInnoGI Technologies, Thijsseweg 11, 2629 JA Delft, The Netherlands.
Inese SarcevicaDrug Product Design, Pfizer, Discovery Park, Ramsgate Road, Sandwich CT13 9ND, UK.
Kieran SmithDrug Product Design, Pfizer, Discovery Park, Ramsgate Road, Sandwich CT13 9ND, UK.
Irena TomaszewskaDrug Product Design, Pfizer, Discovery Park, Ramsgate Road, Sandwich CT13 9ND, UK.
Eleanor JonesStrathclyde Institute of Biopharmaceutical Sciences, University of Strathclyde, Glasgow G1 1XQ, UK.ORCID 0000-0002-3926-6493
Hannah BatchelorStrathclyde Institute of Biopharmaceutical Sciences, University of Strathclyde, Glasgow G1 1XQ, UK.ORCID 0000-0002-8729-9951
Susann BellmannInnoGI Technologies, Thijsseweg 11, 2629 JA Delft, The Netherlands.

Funding

Engineering and Physical Sciences Research Council EP/W036452/1Innovative Medicines Initiative 115369
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

bioaccessibilitybiorelevant dissolutionin vitro dissolutionin vitro gastrointestinal modelTIM-1tiny-TIM

Identifiers

PMID42076053
PMCPMC13118535

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.