Cholinesterase Inhibitory Activity of Alkylated Quinobenzothiazinium Salts.

Sarka Stepankova, Andrzej Bak, Malgorzata Latocha, Violetta Kozik, Agata Kawulok, Josef Jampilek, Andrzej Zieba

Abstract read

In one paragraph

Article in Molecules (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Sarka StepankovaDepartment of Biological and Biochemical Sciences, Faculty of Chemical Technology, University of Pardubice, Studentska 573, 532 10 Pardubice, Czech Republic.ORCID 0000-0002-1969-5258

Andrzej BakInstitute of Chemistry, University of Silesia, Szkolna 9, 40-007 Katowice, Poland.ORCID 0000-0002-9842-1289

Malgorzata LatochaDepartment of Cell Biology, Faculty of Pharmaceutical Sciences, Sosnowiec Medical University of Silesia, Jednosci 9, 41-200 Sosnowiec, Poland.ORCID 0000-0003-4109-2629

Violetta KozikInstitute of Chemistry, University of Silesia, Szkolna 9, 40-007 Katowice, Poland.

Agata KawulokInstitute of Chemistry, University of Silesia, Szkolna 9, 40-007 Katowice, Poland.

Josef JampilekInstitute of Chemistry, University of Silesia, Szkolna 9, 40-007 Katowice, Poland.ORCID 0000-0003-2003-9052

Andrzej ZiebaDepartment of Organic Chemistry, Faculty of Pharmaceutical Sciences, Sosnowiec Medical University of Silesia, Jagiellonska 4, 41-200 Sosnowiec, Poland.ORCID 0000-0002-7841-3097

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ten substituted quinobenzothiazinium salts were tested for their ability to inhibit acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). All the compounds inhibited AChE in the IC

Indexed as

Cholinesterase InhibitorsThiazinesAcetylcholinesteraseAlkylationButyrylcholinesteraseHumansMolecular Docking SimulationMolecular StructureSaltsStructure-Activity RelationshipAcetylcholinesteraseButyrylcholinesteraseCholinesterase InhibitorsSaltsThiazinesADMEAlzheimer’s diseasecholinesterase inhibitory activitymolecular dockingquinobenzothiazinium saltssimilarity–activity landscape index

Identifiers

PMID42076024

DOI10.3390/molecules31081346

PMCPMC13118828

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.