Evidence map›Paper›PMID 42076020›Full record

ArticleMolecules (Basel, Switzerland)2026

Network Silsesquioxane-Based Organogel/Silicone Composites for the Long-Lasting Delivery of Nitric Oxide.

Kyle D Hallowell, Fatima Naser Aldine, Hope N Vonder Brink, Ashley K Mockensturm, Hitesh Handa, Elizabeth J Brisbois, Alexis D Ostrowski, Joseph C Furgal

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Kyle D HallowellDepartment of Chemistry and Center for Photochemical Sciences, Bowling Green State University, Bowling Green, OH 43403, USA.
Fatima Naser AldineDepartment of Chemistry and Center for Photochemical Sciences, Bowling Green State University, Bowling Green, OH 43403, USA.ORCID 0009-0003-0688-3238
Hope N Vonder BrinkDepartment of Chemistry and Center for Photochemical Sciences, Bowling Green State University, Bowling Green, OH 43403, USA.
Ashley K MockensturmDepartment of Chemistry and Center for Photochemical Sciences, Bowling Green State University, Bowling Green, OH 43403, USA.
Hitesh HandaSchool of Chemical, Materials, and Biomedical Engineering, University of Georgia, Athens, GA 30602, USA.ORCID 0000-0002-9369-7374
Elizabeth J BrisboisSchool of Chemical, Materials, and Biomedical Engineering, University of Georgia, Athens, GA 30602, USA.ORCID 0000-0002-9283-5448
Alexis D OstrowskiDepartment of Chemistry and Center for Photochemical Sciences, Bowling Green State University, Bowling Green, OH 43403, USA.ORCID 0000-0002-3207-1845
Joseph C FurgalDepartment of Chemistry and Center for Photochemical Sciences, Bowling Green State University, Bowling Green, OH 43403, USA.ORCID 0000-0002-7040-0793

Funding

Long-term and Mediated NO-Release Silicone Polymers for Blood Interface DevicesR15HL168693 · NHLBI · BOWLING GREEN STATE UNIVERSITY · PI FURGAL, JOSEPH · 2023 to 2023
$434k
Bowling Green State University Startup FundsNational Heart Lung and Blood Institute 1R15HL168693-01NHLBI NIH HHS R15 HL168693
6 · The paper itself

Abstract

Nitric oxide (NO) is a gaseous biocompatible radical molecule with demonstrated biomedical and antimicrobial benefits. Developing adaptable, long-lasting delivery systems for NO has become an essential goal for both combating resistant bacterial growth and providing sustained medical benefits. Silsesquioxane (SQ)-based organogels were chosen and synthesized as robust, tunable NO-release platforms. These highly stable SQ gel frameworks, composed of silicon-oxygen backbones with variable R groups, exhibited high porosity and surface area and offered chemical versatility, enabling control over NO loading and release. 3-Mercaptopropyl groups were utilized as sulfur-based NO-releasing substituents (-RSNOs), with additional R groups capable of altering accessibility to RSNO sites through hydrophobicity and steric hindrance. The NO release profile, rate, and duration of the functionalized gels were also tailored by adjusting the number of RSNO sites in the elastomeric system, thereby enabling a customizable release profile. This combination of NO-releasing silsesquioxanes with silicone elastomers yields composite materials that are integratable into biomedical applications, offering NO release up to 40 days within modeled physiological conditions in PBS buffer.

Indexed as

Drug Delivery SystemsNitric OxideOrganosilicon CompoundsSiliconesGelsPorosityGelsNitric OxideOrganosilicon CompoundsSiliconesbiomedical materialsnitric oxide (NO) releasenitrosothiolorganogel-RSNOsilsesquioxanes

Identifiers

PMID42076020
PMCPMC13119455

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.