ArticleMolecules (Basel, Switzerland)2026
DBU-Mediated Diastereoselective (3+2)-Cycloaddition of Isatin Ketonitrones and Coumarins to Construct Coumarin-Fused Spiropyrolidine Oxoindoles.
Article in Molecules (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
The synthesis of novel dicyclic spiropyrrolidine oxoindole derivatives is described. This approach relies on a (3+2)-cycloaddition reaction between coumarins and isatin ketonitrone 1,3-dipoles, which were formed in situ by condensation of various substituted isatins with arylhydroxylamines. The corresponding pentacyclic products, featuring four contiguous stereocenters-including two quaternary carbon stereocenters fused within a single ring system-were obtained smoothly in moderate to excellent yields (22-98%), with high regioselectivity (
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