Evidence map›Paper›PMID 42075972›Full record

ArticleMolecules (Basel, Switzerland)2026

Catalase Specifically Binds Antipsychotic Clozapine: Experimental and In Silico Insights into Interactions, Complex Stability, and Dose-Dependent Enzyme Activity Modulation.

Tamara Vasović, Milica Radibratović, Dušan Spasić, Simeon Minić, Čedo Miljević, Nikola Gligorijević, Milan Nikolić

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Tamara VasovićDepartment of Biochemistry, Faculty of Chemistry, University of Belgrade, 11000 Belgrade, Serbia.ORCID 0000-0001-6119-7220
Milica RadibratovićDepartment of Chemistry, Institute for Chemistry, Technology and Metallurgy, National Institute of the Republic of Serbia, University of Belgrade, 11000 Belgrade, Serbia.
Dušan SpasićDepartment of Pharmacology, Clinical Pharmacology and Toxicology, Faculty of Medicine, University of Belgrade, 11000 Belgrade, Serbia.
Simeon MinićDepartment of Biochemistry, Faculty of Chemistry, University of Belgrade, 11000 Belgrade, Serbia.
Čedo MiljevićInstitute of Mental Health, Faculty of Medicine, University of Belgrade, 11000 Belgrade, Serbia.
Nikola GligorijevićDepartment of Chemistry, Institute for Chemistry, Technology and Metallurgy, National Institute of the Republic of Serbia, University of Belgrade, 11000 Belgrade, Serbia.ORCID 0000-0002-8691-2486
Milan NikolićDepartment of Biochemistry, Faculty of Chemistry, University of Belgrade, 11000 Belgrade, Serbia.ORCID 0000-0003-0932-889X

Funding

Ministry of Science, Technological Development, and Innovation of the Republic of Serbia 451-03-33/2026-03/200168, 451-03-33/2026-03/200026
6 · The paper itself

Abstract

Oxidative stress is intrinsically linked to mental disorders, involving an imbalance between reactive species and antioxidant defenses, where catalase is an essential, ubiquitous antioxidant enzyme. The pleiotropic effects of antipsychotic drugs, used for schizophrenia and mood disorders, are not fully elucidated at the molecular level. This study characterized the binding of a highly effective but potentially dangerous antipsychotic, clozapine (CLZ), to commercial bovine liver catalase (BLC). Using various spectroscopic methods under simulated physiological conditions, we found a moderate binding affinity of CLZ for BLC (

Indexed as

Antipsychotic AgentsCatalaseClozapineAnimalsAntioxidantsBinding SitesCatalytic DomainCattleEnzyme StabilityMolecular Docking SimulationMolecular Dynamics SimulationOxidation-ReductionProtein BindingAntioxidantsAntipsychotic AgentsCatalaseClozapinebinding interactionscatalaseclozapineenzyme activityenzyme structure

Identifiers

PMID42075972
PMCPMC13118352

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.