Evidence map›Paper›PMID 42075931›Full record

ArticleMolecules (Basel, Switzerland)2026

Rapid Quantification of Ceftobiprole in Human Plasma and Cerebrospinal Fluid by LC-MS/MS and Its Application in Patients with Central Nervous System Infections.

Sabahat Ablimit, Wanzhen Li, Mengting Chen, Jing Zhang, Nanyang Li, Yaxin Fan, Muyassar Yasen, Mubarak Iminjan, Beining Guo

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Sabahat AblimitCollege of Pharmacy, Xinjiang Medical University, Urumqi 830017, China.
Wanzhen LiInstitute of Antibiotics, Key Laboratory of Clinical Pharmacology of Antibiotics, National Clinical Research Center for Aging and Medicine, Professional Technical Service Platform for Comprehensive Preclinical Pharmacodynamic Evaluation and Clinical Translation of Antibacterial Agents, Joint Laboratory of Hospital & Enterprise for Pathogen Diagnosis of Drug-Resistant Bacterial lnfections and lnnovative Drug R&D, Huashan Hospital, Fudan University, Shanghai 200040, China.
Mengting ChenInstitute of Antibiotics, Key Laboratory of Clinical Pharmacology of Antibiotics, National Clinical Research Center for Aging and Medicine, Professional Technical Service Platform for Comprehensive Preclinical Pharmacodynamic Evaluation and Clinical Translation of Antibacterial Agents, Joint Laboratory of Hospital & Enterprise for Pathogen Diagnosis of Drug-Resistant Bacterial lnfections and lnnovative Drug R&D, Huashan Hospital, Fudan University, Shanghai 200040, China.
Jing ZhangInstitute of Antibiotics, Key Laboratory of Clinical Pharmacology of Antibiotics, National Clinical Research Center for Aging and Medicine, Professional Technical Service Platform for Comprehensive Preclinical Pharmacodynamic Evaluation and Clinical Translation of Antibacterial Agents, Joint Laboratory of Hospital & Enterprise for Pathogen Diagnosis of Drug-Resistant Bacterial lnfections and lnnovative Drug R&D, Huashan Hospital, Fudan University, Shanghai 200040, China.ORCID 0000-0003-2966-9149
Nanyang LiClinical Pharmacology Research Center, Huashan Hospital, Fudan University, Shanghai 200040, China.
Yaxin FanInstitute of Antibiotics, Key Laboratory of Clinical Pharmacology of Antibiotics, National Clinical Research Center for Aging and Medicine, Professional Technical Service Platform for Comprehensive Preclinical Pharmacodynamic Evaluation and Clinical Translation of Antibacterial Agents, Joint Laboratory of Hospital & Enterprise for Pathogen Diagnosis of Drug-Resistant Bacterial lnfections and lnnovative Drug R&D, Huashan Hospital, Fudan University, Shanghai 200040, China.ORCID 0000-0002-1403-8072
Muyassar YasenCollege of Pharmacy, Xinjiang Medical University, Urumqi 830017, China.
Mubarak IminjanCollege of Pharmacy, Xinjiang Medical University, Urumqi 830017, China.
Beining GuoInstitute of Antibiotics, Key Laboratory of Clinical Pharmacology of Antibiotics, National Clinical Research Center for Aging and Medicine, Professional Technical Service Platform for Comprehensive Preclinical Pharmacodynamic Evaluation and Clinical Translation of Antibacterial Agents, Joint Laboratory of Hospital & Enterprise for Pathogen Diagnosis of Drug-Resistant Bacterial lnfections and lnnovative Drug R&D, Huashan Hospital, Fudan University, Shanghai 200040, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ceftobiprole is a fifth-generation beta-cephalosporin with high inter-individual pharmacokinetic variability in critically ill patients. However, data on its pharmacokinetics and central nervous system (CNS) penetration are limited. This study developed and validated a rapid LC-MS/MS method for quantifying ceftobiprole in human plasma and CSF. Sample preparation involved protein precipitation of 50 µL aliquots. Analysis used gradient elution on an ACQUITY UPLC

Indexed as

Anti-Bacterial AgentsCentral Nervous System InfectionsCephalosporinsTandem Mass SpectrometryChromatography, LiquidHumansLiquid Chromatography-Mass SpectrometryReproducibility of ResultsAnti-Bacterial AgentsceftobiproleCephalosporinsceftobiprolecerebrospinal fluidliquid chromatography–tandem mass spectrometrypenetrationplasma

Identifiers

PMID42075931
PMCPMC13119386

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.