ArticleMolecules (Basel, Switzerland)2026
Experimental and MEDT Study of Sydnone-Alkyne Cycloaddition-Based Synthesis of 1,4-Disubstituted Pyrazoles and In Silico Investigation of Their Binding to HCV and HIV Proteins.
Souad Zerbib, Mohammed Eddahmi, Marwa Alaqarbeh, Pierre-Edouard Bodet, Valérie Thiery, Ahmed Fatimi, Natália Cruz-Martins, Christian Bailly, Luis R Domingo, Latifa Bouissane
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In one paragraphArticle in Molecules (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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10 authors.
Souad ZerbibLaboratory of Molecular Chemistry, Materials and Catalysis, Faculty of Sciences and Technologies, Sultan Moulay Slimane University, BP 523, Beni-Mellal 23000, Morocco.ORCID 0009-0000-1919-4480 Mohammed EddahmiSustainable Processes, Advanced Materials and Computational Chemistry Team, Polydisciplinary Faculty of Beni Mellal, Sultan Moulay Slimane University, Mghila, P.O. Box 592, Beni Mellal 23000, Morocco.ORCID 0000-0003-0051-512X Marwa AlaqarbehApplied Science Research Center, Applied Science Private University, Amman 11931, Jordan.
Pierre-Edouard BodetPlateforme d'Analyse Haute Résolution des Biomolécules PAHRB, LIttoral, ENvironment and Societies (LIENSs), UMR CNRS 7266, Université de La Rochelle, 17042 La Rochelle, France.ORCID 0000-0003-1904-4823 Valérie ThieryLIttoral, ENvironment and Societies (LIENSs), UMR CNRS 7266, Université de La Rochelle, Rue Olympe de Gouges, 17042 La Rochelle, France.ORCID 0000-0002-2096-0098 Ahmed FatimiChemical Science and Engineering Research Team, Department of Chemistry, Polydisciplinary Faculty of Beni-Mellal, Sultan Moulay Slimane University, Beni-Mellal 23000, Morocco.ORCID 0000-0001-8749-2009 Natália Cruz-MartinsLife and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, P.O. Box 4710-057 Braga, Portugal.ORCID 0000-0002-5934-5201 Christian BaillyInstitute of Pharmaceutical Chemistry Albert Lespagnol (ICPAL), Faculty of Pharmacy, University of Lille, rue du Professeur Laguesse, BP-83, F-59006 Lille, France.ORCID 0000-0002-2973-9357 Latifa BouissaneSustainable Processes, Advanced Materials and Computational Chemistry Team, Polydisciplinary Faculty of Beni Mellal, Sultan Moulay Slimane University, Mghila, P.O. Box 592, Beni Mellal 23000, Morocco.ORCID 0000-0002-2231-1956 Funding
No grant is acknowledged in the PubMed record.
6 · The paper itselfAbstract
Six 1,4-disubstituted pyrazoles linked to a benzenesulfonamide and a benzodioxane unit have been synthesized through a copper(I)-catalyzed formal [3+2] cycloaddition (32CA) reaction of alkynes with 3-arylsydnones. The Cu-catalyzed sydnone-alkyne cycloaddition (CuSAC) procedure has been optimized to promote the formation of the pyrazole ring and to deliver in three steps the six target compounds
Indexed as
AlkynesHepacivirusPyrazolesSydnonesCatalysisCycloaddition ReactionDensity Functional TheoryHumansMolecular Docking SimulationMolecular StructureProtein BindingAlkynesPyrazolesSydnones1,4-benzodioxane1,4-disubstituted pyrazoleCuSACcyclophilin Agp120 bindingMEDTmolecular dockingsydnone
Identifiers
PMID42075930
PMCPMC13118465
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