Evidence map›Paper›PMID 42075921›Full record

ReviewMolecules (Basel, Switzerland)2026

Application of Single-Atom Nanozymes in the Detection of Small Biomolecules: A Review.

Wanyi Zhang, Rong Huang, Wenhui Luo, Xiaojing Si, Dongmei Deng, Liqiang Luo

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Molecules (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Wanyi ZhangCollege of Sciences, Shanghai University, Shanghai 200444, China.
Rong HuangCollege of Sciences, Shanghai University, Shanghai 200444, China.
Wenhui LuoCollege of Sciences, Shanghai University, Shanghai 200444, China.
Xiaojing SiDepartment of Food Science and Nutrition, Shanghai Business School, Shanghai 200235, China.ORCID 0000-0001-9477-9577
Dongmei DengCollege of Sciences, Shanghai University, Shanghai 200444, China.
Liqiang LuoCollege of Sciences, Shanghai University, Shanghai 200444, China.ORCID 0000-0002-5551-3861

Funding

National Natural Science Foundation of China 61971274National Natural Science Foundation of China 62171268National Natural Science Foundation of China 62571308
6 · The paper itself

Abstract

Single-atom nanozymes (SANs) with atomically dispersed metal sites show great potential in small biomolecule detection. This review first summarizes SAN synthesis (wet chemistry, atomic layer deposition, etc.), structural features (tunable coordination, metal-carrier interactions), and catalytic mechanisms (synergistic effects, d-band modulation). Afterwards, this review focuses on the applications of SANs in detecting small biomolecules, including glucose, glutathione, uric acid, ascorbic acid, hydrogen peroxide, and dopamine via colorimetry, fluorescence, and electrochemistry. Challenges such as matrix interference and stability, along with future directions in flexible electronics and clinical translation, are discussed, aiming to advance SAN-based detection technologies.

Indexed as

Biosensing TechniquesNanostructuresAscorbic AcidCatalysisColorimetryDopamineGlucoseGlutathioneHumansHydrogen PeroxideUric AcidAscorbic AcidDopamineGlucoseGlutathioneHydrogen PeroxideUric Aciddetectionsingle-atom nanozymessmall biomolecules

Identifiers

PMID42075921
PMCPMC13118450

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.